Université de Fribourg

Yeast growth selection system for the identification of cell-active inhibitors of human cytomegalovirus protease

Cottier, Valérie ; Müller, Fritz (Dir.)

Thèse de doctorat : Université de Fribourg, 2006 ; no 1501.

Human cytomegalovirus (HCMV) is one of the most common opportunistic infective agents in immunocompromised individuals, such as AIDS patients and organ transplant recipients, and causes the most frequent congenital infection in humans. Existing antiviral treatments are limited by severe drawbacks, i.e. poor bioavailability, toxicity and limited effectiveness mainly due to the development of drug...

Université de Neuchâtel

β-Aminobutyric Acid-induced Resistance in Plants

Jakab, Gabor ; Cottier, Valérie ; Toquin, Valérie ; Rigoli, Ghislaine ; Zimmerli, Laurent ; Métraux, Jean-Pierre ; Mauch-Mani, Brigitte

In: European Journal of Plant Pathology, 2001, vol. 107, no. 1, p. 29-37

The broad sprectrum protective effect of the non-protein amino acid β-aminobutyric acid (BABA) against numerous plant diseases has been well-documented in the literature. Here, we present an overview of BABA-induced protection in various pathosystems. Contriidictory reports concerning the mechanism of action underlying this type of protection incited us to take advantage of Arabidopsis/pathogen...