Università della Svizzera italiana

Potential of PEGylated toll-like receptor 7 ligands for controlling inflammation and functional changes in mouse models of asthma and silicosis

Teixeira Ferreira, Tatiana Paula ; Lacerda Mariano, Lívia ; Ghilosso-Bortolini, Roberta ; Santos de Arantes, Ana Carolina ; Fernandes, Andrey Junior ; Berni, Michelle ; Cecchinato, Valentina ; Uguccioni, Mariagrazia ; Maj, Roberto ; Barberis, Alcide ; Machado Rodrigues Silva, Patricia ; Martins, Marco Aurélio

In: Frontiers in immunology, 2016, vol. 7, p. 95

Prior investigations show that signaling activation through pattern recognition receptors can directly impact a number of inflammatory lung diseases. While toll-like receptor (TLR) 7 agonists have raised interest for their ability to inhibit allergen-induced pathological changes in experimental asthma conditions, the putative benefit of this treatment is limited by adverse effects. Our aim...

Università della Svizzera italiana

Chemokine heterocomplexes and cancer : A novel chapter to be written in tumor immunity

D'Agostino, Gianluca ; Cecchinato, Valentina ; Uguccioni, Mariagrazia

In: Frontiers in immunology, 2018, vol. 9, p. 2185

Infiltrating immune cells are a key component of the tumor microenvironment and play central roles in dictating tumor fate, either promoting anti-tumor immune responses, or sustaining tumor growth, angiogenesis and metastasis. A distinctive microenvironment is often associated to different tumor types, with substantial differences in prognosis. The production of a variety of chemotactic...

Università della Svizzera italiana

Redox-mediated mechanisms fuel monocyte responses to CXCL12/HMGB1 in active rheumatoid arthritis

Cecchinato, Valentina ; D'Agostino, Gianluca ; Raeli, Lorenzo ; Nerviani, Alessandra ; Schiraldi, Milena ; Danelon, Gabriela ; Manzo, Antonio ; Thelen, Marcus ; Ciurea, Adrian ; Bianchi, Marco E. ; Rubartelli, Anna ; Pitzalis, Costantino ; Uguccioni, Mariagrazia

In: Frontiers in immunology, 2018, vol. 9, p. 2118

Chemokine synergy-inducing molecules are emerging as regulating factors in cell migration. The alarmin HMGB1, in its reduced form, can complex with CXCL12 enhancing its activity on monocytes via the chemokine receptor CXCR4, while the form containing a disulfide bond, by binding to TLR2 or TLR4, initiates a cascade of events leading to production of cytokines and chemokines. So far, the...