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Université de Fribourg

Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock

Brenna, Andrea ; Olejniczak, Iwona ; Chavan, Rohit ; Ripperger, Jürgen A ; Langmesser, Sonja ; Cameroni, Elisabetta ; Hu, Zehan ; De Virgilio, Claudio ; Dengjel, Jörn ; Albrecht, Urs

In: eLife, 2019, vol. 8, p. e50925

Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases. In mammals, the kinase promoting the nuclear import of the key clock component Period 2 (PER2) is unknown. Here, we show that the cyclin-dependent kinase 5...

Università della Svizzera italiana

Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae

Pennini, Meghan E. ; De Marco, Anna ; Pelletier, Mark ; Bonnell, Jessica ; Cvitkovic, Romana ; Beltramello, Martina ; Cameroni, Elisabetta ; Bianchi, Siro ; Zatta, Fabrizia ; Zhao, Wei ; Xiao, Xiaodong ; Camara, Maria M. ; DiGiandomenico, Antonio ; Semenova, Elena ; Lanzavecchia, Antonio ; Warrener, Paul ; Suzich, JoAnn ; Wang, Qun ; Corti, Davide ; Stover, C. Kendall

In: Nature communications, 2017, vol. 8, p. 1991

Emerging multidrug-resistant bacteria are a challenge for modern medicine, but how these pathogens are so successful is not fully understood. Robust antibacterial vaccines have prevented and reduced resistance suggesting a pivotal role for immunity in deterring antibiotic resistance. Here, we show the increased prevalence of Klebsiella pneumoniae lipopolysaccharide O2 serotype strains in all...

Università della Svizzera italiana

Expression of the chemokine receptor CXCR7 in CXCR4-expressing human 143B osteosarcoma cells enhances lung metastasis of intratibial xenografts in SCID mice

Brennecke, Patrick ; Arlt, Matthias J. E. ; Muff, Roman ; Campanile, Carmen ; Gvozdenovic, Ana ; Husmann, Knut ; Holzwarth, Nathalie ; Cameroni, Elisabetta ; Ehrensperger, Felix ; Thelen, Marcus ; Born, Walter ; Fuchs, Bruno

In: Plos one, 2013, vol. 8, no. 9, p. e74045

More effective treatment of metastasizing osteosarcoma with a current mean 5-year survival rate of less than 20% requires more detailed knowledge on mechanisms and key regulatory molecules of the complex metastatic process. CXCR4, the receptor of the chemokine CXCL12, has been reported to promote tumor progression and metastasis in osteosarcoma. CXCR7 is a recently deorphanized...

Università della Svizzera italiana

CCR2 acts as scavenger for CCL2 during monocyte chemotaxis

Volpe, Silvia ; Cameroni, Elisabetta ; Moepps, Barbara ; Thelen, Sylvia ; Apuzzo, Tiziana ; Thelen, Marcus

In: Plos one, 2012, vol. 7, no. 5, p. e37208

Background: Leukocyte migration is essential for effective host defense against invading pathogens and during immune homeostasis. A hallmark of the regulation of this process is the presentation of chemokines in gradients stimulating leukocyte chemotaxis via cognate chemokine receptors. For efficient migration, receptor responsiveness must be maintained whilst the cells crawl on cell surfaces...

Università della Svizzera italiana

CXCR7 functions as a scavenger for CXCL12 and CXCL11

Naumann, Ulrike ; Cameroni, Elisabetta ; Pruenster, Monika ; Mahabaleshwar, Harsha ; Raz, Erez ; Zerwes, Hans-Günter ; Rot, Antal ; Thelen, Marcus

In: Plos one, 2010, vol. 5, no. 2, p. e9175

Background: CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is controversial. Some studies suggest a signaling activity in mammalian cells and zebrafish embryos, while others indicate a decoy...

Université de Fribourg

The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability

Wilms, Tobias ; Swinnen, Erwin ; Eskes, Elja ; Dolz-Edo, Laura ; Uwineza, Alice ; Essche, Ruben Van ; Rosseels, Joëlle ; Zabrocki, Piotr ; Cameroni, Elisabetta ; Franssens, Vanessa ; Virgilio, Claudio De ; Smits, Gertien J. ; Winderickx, Joris

In: PLOS Genetics, 2017, vol. 13, no. 6, p. e1006835

The evolutionary conserved TOR complex 1 controls growth in response to the quality and quantity of nutrients such as carbon and amino acids. The protein kinase Sch9 is the main TORC1 effector in yeast. However, only few of its direct targets are known. In this study, we performed a genome-wide screening looking for mutants which require Sch9 function for their survival and growth. In this...

Université de Fribourg

Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway

Talarek, Nicolas ; Cameroni, Elisabetta ; Jaquenoud, Malika ; Luo, Xuan ; Bontron, Séverine ; Lippman, Soyeon ; Devgan, Geeta ; Snyder, Michael ; Broach, James R. ; De Virgilio, Claudio

In: Molecular Cell, 2010, vol. 38, no. 3, p. 345-355

Eukaryotic cell proliferation is controlled by growth factors and essential nutrients, in the absence of which cells may enter into a quiescent (G0) state. In yeast, nitrogen and/or carbon limitation causes downregulation of the conserved TORC1 and PKA signaling pathways and, consequently, activation of the PAS kinase Rim15, which orchestrates G0 program initiation and ensures proper life span by...

Université de Fribourg

Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs

Mok, Janine ; Kim, Philip M. ; Lam, Hugo Y. K. ; Piccirillo, Stacy ; Zhou, Xiuqiong ; Jeschke, Grace R. ; Sheridan, Douglas L. ; Parker, Sirlester A. ; Desai, Ved ; Jwa, Miri ; Cameroni, Elisabetta ; Niu, Hengyao ; Good, Matthew ; Remenyi, Attila ; Ma, Jia-Lin Nianhan ; Sheu, Yi-Jun ; Sassi, Holly E. ; Sopko, Richelle ; Chan, Clarence S. M. ; De Virgilio, Claudio ; Hollingsworth, Nancy M. ; Lim, Wendell A. ; Stern, David F. ; Stillman, Bruce ; Andrews, Brenda J. ; Gerstein, Mark B. ; Snyder, Michael ; Turk, Benjamin E.

In: Science Signaling, 2010, vol. 3, no. 109, p. ra12

Phosphorylation is a universal mechanism for regulating cell behavior in eukaryotes. Although protein kinases target short linear sequence motifs on their substrates, the rules for kinase substrate recognition are not completely understood. We used a rapid peptide screening approach to determine consensus phosphorylation site motifs targeted by 61 of the 122 kinases in Saccharomyces cerevisiae....