Université de Fribourg

The orbitofrontal cortex projects to the parvafox nucleus of the ventrolateral hypothalamus and to its targets in the ventromedial periaqueductal grey matter

Babalian, Alexandre ; Eichenberger, Simone ; Bilella, Alessandro ; Girard, Franck ; Szabolcsi, Viktoria ; Roccaro, Diana ; Alvarez-Bolado, Gonzalo ; Xu, Chun ; Celio, Marco R.

In: Brain Structure and Function, 2019, vol. 224, no. 1, p. 293–314

Although connections between the orbitofrontal cortex (OFC)—the seat of high cognitive functions—the lateral hypothalamus and the periaqueductal grey (PAG) have been recognized in the past, the precise targets of the descending fibres have not been identified. In the present study, viral tracer-transport experiments revealed neurons of the lateral (LO) and the ventrolateral (VLO) OFC...

Université de Fribourg

The Foxb1‐expressing neurons of the ventrolateral hypothalamic parvafox nucleus project to defensive circuits

Bilella, Alessandro ; Alvarez-Bolado, Gonzalo ; Celio, Marco R.

In: Journal of Comparative Neurology, 2016, vol. 524, no. 15, p. 2955–2981

The parvafox nucleus is an elongated structure that is lodged within the ventrolateral hypothalamus and lies along the optic tract. It comprises axially located parvalbumin (Parv)-positive neurons and a peripheral cuff of Foxb1-expressing ones. In the present study, injections of Cre-dependent adenoviral constructs were targeted to the ventrolateral hypothalamus of Foxb1/Cre mice to label...

Université de Fribourg

Birthdate of parvalbumin-neurons in the Parvafox-nucleus of the lateral hypothalamus

Bilella, Alessandro ; Alvarez-Bolado, Gonzalo ; Celio, Marco R.

In: Brain Research, 2016, vol. 1633, p. 111–114

The Parvafox-nucleus in the lateral hypothalamus is characterized by the presence of two distinct neural populations, the Parvalbumin (Parv) and the Foxb1-expressing ones. Foxb1-neurons are born at day 10 in the subventricular zone of the mouse mammillary region. It would be interesting to know if the subpopulation of Parv- neurons develop independently at different times and then meet the...

Université de Fribourg

Coaxiality of Foxb1- and parvalbumin-expressing neurons in the lateral hypothalamic PV1-nucleus

Bilella, Alessandro ; Alvarez-Bolado, Gonzalo ; Celio, Marco R.

In: Neuroscience Letters, 2014, vol. 566, p. 111–114

In the ventrolateral hypothalamus, the PV1-nucleus is defined by its population of parvalbumin-expressing neurons. During embryogenesis, the ventrolateral hypothalamus is colonized also by Foxb1-expressing neurons. In adult Foxb1-EGFP mice, many immunofluorescent neurons were found within the region that is occupied by the PV1-nucleus. They formed a cloud around the axial cord of the...