Université de Fribourg

Impulsivity and home-cage activity are decreased by lentivirus-mediated silencing of serotonin transporter in the rat hippocampus

Zoratto, Francesca ; Tringle, Amanda L. ; Bellenchi, Giancarlo ; Speranza, Luisa ; Travaglini, Domenica ; diPorzio, Umberto ; Perrone-Capano, Carla ; Laviola, Giovanni ; Dreyer, Jean-Luc ; Adriani, Walter

In: Neuroscience Letters, 2013, vol. 548, p. 38–43

Brain serotonin (5-HT) systems modulate emotional, motivational and cognitive processes. Mutations in the serotonin transporter (SERT) gene have been associated with susceptibility towards the development of several psychiatric disorders, both in humans and animal models. Present approach exploited a bilateral intra-hippocampus stereotaxic inoculation of lentiviruses, for enduring in vivo...