Consortium of Swiss Academic Libraries

Vascular remodeling by intussusceptive angiogenesis

Djonov, Valentin ; Baum, Oliver ; Burri, Peter

In: Cell and Tissue Research, 2003, vol. 314, no. 1, p. 107-117

Université de Fribourg

Decrease in VEGF expression induces intussusceptive vascular pruning

Hlushchuk, Ruslan ; Ehrbar, Martin ; Reichmuth, Philipp ; Heinimann, Niklas ; Styp-Rekowska, Beata ; Escher, Robert ; Baum, Oliver ; Lienemann, Philipp ; Makanya, Andrew ; Keshet, Eli ; Djonov, Valentin

In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2011, vol. 31, p. 2836-2844

Objective—The concept of vascular pruning, the “cuting-off” of vessels, is gaining importance due to expansion of angio-modulating therapies. The proangiogenic effects of vascular endothelial growth factor (VEGF) are broadly described, but the mechanisms of structural alterations by its downregulation are not known.Methods and Results—VEGF165-releasing hydrogels were applied onto the...

Université de Fribourg

Tumor recovery by angiogenic switch from sprouting to intussusceptive angiogenesis after treatment with PTK787/ZK222584 or ionizing radiation

Hlushchuk, Ruslan ; Riesterer, Oliver ; Baum, Oliver ; Wood, Jeanette ; Gruber, Guenther ; Pruschy, Martin ; Djonov, Valentin

In: American Journal of Pathology, 2009, vol. 173, p. 1173-1185

Inhibitors of angiogenesis and radiation induce compensatory changes in the tumor vasculature both during and after treatment cessation. To assess the responses to irradiation and vascular endothelial growth factor-receptor tyrosine kinase inhibition (by the vascular endothelial growth factor tyrosine kinase inhibitor PTK787/ZK222854), mammary carcinoma allografts were investigated by vascular...