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PARP inhibition induces Akt-mediated cytoprotective effects through the formation of a mitochondria-targeted phospho-ATM-NEMO-Akt-mTOR signalosome

Tapodi, Antal ; Bognar, Zita ; Szabo, Csaba ; Gallyas, Ferenc ; Sumegi, Balázs ; Hocsak, Enikő

In: Biochemical Pharmacology, 2019, vol. 162, p. 98–108

The cytoprotective effect of poly(ADP-ribose) polymerase 1 (PARP1) inhibition is well documented in various cell types subjected to oxidative stress. Previously, we have demonstrated that PARP1 inhibition activates Akt, and showed that this response plays a critical role in the maintenance of mitochondrial integrity and in cell survival. However, it has not yet been defined how nuclear PARP1...