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Université de Fribourg

Boron isotope composition of the cold-water coral Lophelia pertusa along the Norwegian margin: Zooming into a potential pH-proxy by combining bulk and high-resolution approaches

Jurikova, Hana ; Liebetrau, Volker ; Raddatz, Jacek ; Fietzke, Jan ; Trotter, Julie ; Rocholl, Alexander ; Krause, Stefan ; Mc Culloch, Malcolm ; Rüggeber, Andres ; Eisenhauer, Anton

In: Chemical Geology, 2019, vol. 513, p. 143–152

High-latitude cold-water coral reefs are particularly vulnerable to climate change due to enhanced CO2 uptake in these regions. To evaluate their physiological functioning and potential application as pH archives, we retrieved both recent and fossil samples of Lophelia pertusa along the Norwegian margin from Oslofjord (59°N), over to Trondheimsfjord, Sula and Lopphavet (70.6°N). Boron...

Université de Fribourg

Comparison of conventional and individualized 1-MET values for expressing maximum aerobic metabolic rate and habitual activity related energy expenditure

Heydenreich, Juliane ; Schutz, Yves ; Melzer, Katarina ; Kayser, Bengt

In: Nutrients, 2019, vol. 11, no. 2, p. 458

The maximum aerobic metabolic rate can be expressed in multiple metabolically equivalent tasks (MET), i.e., METmax. The purpose was to quantify the error when the conventional (3.5 mL∙kg−1∙min−1) compared to an individualized 1-MET-value is used for calculating METmax and estimating activity energy expenditure (AEE) in endurance-trained athletes (END) and active healthy controls...

Université de Fribourg

A bio-inspired amplification cascade for the detection of rare cancer cells

Rüegg, Curzio ; Reis, Corine ; Rafiee, Sarah ; Rodriguez-Lorenzoa, Laura ; List, Jonathan ; Rothen-Rutishauser, Barbara ; Mayer, Michael ; Petri-Fink, Alke

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 63–68

The main cause of cancer-related death is due to cancer cell spreading and formation of secondary tumors in distant organs, the so-called metastases. Metastatic cancer cells are detectable in the blood of cancer patients as circulating tumor cells (CTC) and may be exploited for prognostic and monitoring purposes, including in breast cancer. Due to their very low frequency, however, their...

Università della Svizzera italiana

Enhancing coevolution-based contact prediction by imposing structural self-consistency of the contacts

Kassem, Maher M. ; Christoffersen, Lars B. ; Cavalli, Andrea ; Lindorff-Larsen, Kresten

In: Scientific reports, 2018, vol. 8, no. 1, p. 11112

Based on the development of new algorithms and growth of sequence databases, it has recently become possible to build robust higher-order sequence models based on sets of aligned protein sequences. Such models have proven useful in de novo structure prediction, where the sequence models are used to find pairs of residues that co-vary during evolution, and hence are likely to be in spatial...

Université de Fribourg

Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis

Tiam, Eric Robert ; Ngono Bikobo, Dominique Serge ; Zintchem, Auguste Abouem A. ; Mbabi Nyemeck II, Norbert ; Moni Ndedi, Esther Del Florence ; Betote Diboué, Patrick Hervé ; Nyegue, Maximilienne Ascension ; Atchadé, Alex de Théodore ; Pegnyemb, Dieudonné Emmanuel ; Bochet, Christian G. ; Koert, Ulrich

In: Natural Product Research, 2019, vol. 33, no. 5, p. 642–650

Triclisinone (2), a new ochnaflavone derivative, was isolated from the aerial parts of Triclisia gilletii, along with known drypemolundein B (1) and eight other known compounds. The chemical shifts of drypemolundein B (1) have been partially revised based on reinterpretation of NMR spectroscopic data. The eight other secondary metabolites are composed of: (+)-nonacosan-10-ol (3); stigmasterol...

Université de Fribourg

Modification of sperm fatty acid composition during epididymal maturation in bats

Fasel, Nicolas J. ; McMillian, Kevin ; Jakop, Ulrike ; Méné-Saffrané, Laurent ; Engel, Kathrin M. ; Genoud, Michel ; Müller, Karin ; Christe, Philippe

In: Reproduction, 2019, vol. 157, no. 1, p. 77–85

Biochemical properties of polyunsaturated fatty acids (PUFAs) are fundamental to sperm movements. Amongst all adjustments operated during epididymal maturation, sperm membrane lipid composition is remodelled. Specifically, the proportion of PUFAs usually increases from the caput towards the cauda epididymidis. In mammals, PUFAs are predominantly acquired through the diet, which can ...

Université de Neuchâtel

Semantic content in titi monkey alarm call sequences

Berthet, Mélissa ; Zuberbühler, Klaus (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

The comparative approach aims to understand the uniqueness of human language and how it evolved from primitive communication systems. Black-fronted titi monkeys Callicebus nigrifrons possess two soft alarm calls: A-calls are specific to threats within the canopy while B-calls are general calls emitted to terrestrial predators but also in non-predatory contexts, while moving near the...

Université de Fribourg

A spatially and functionally distinct pool of TORC1 defines signaling endosomes in yeast

Hatakeyama, Riko ; De Virgilio, Claudio

In: Autophagy, 2019, vol. 15, no. 5, p. 915–916

The evolutionarily conserved target of rapamycin complex 1 (TORC1) regulates cell growth in a homeostatic manner by tuning anabolic and catabolic processes in response to nutritional and hormonal cues. Interestingly, rather than being localized at the plasma membrane as perhaps expected for an integrator of extracellular signals, TORC1 mainly localizes at vacuolar (in yeast) and lysosomal (in...

Université de Fribourg

An atomistic look into bio-inspired nanoparticles and their molecular interactions with cells

Petretto, Emanuele ; Campomanes, Pablo ; Stellacci, Francesco ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke ; Vanni, Stefano

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 78–80

Nanoparticles (NPs) have sizes that approach those of pathogens and they can interact with the membranes of eukaryotic cells in an analogous fashion. Typically, NPs are taken up by the cell via the plasma membrane by receptor-mediated processes and subsequently interact with various endomembranes. Unlike pathogens, however, NPs lack the remarkable specificity gained during the evolutionary...

Université de Fribourg

Templated assembly of pore-forming peptides in lipid membranes

Fennouri, Aziz ; List, Jonathan ; Dupasquier, Jessica ; Haeni, Laetitia ; Vanni, Stefano ; Rothen-Rutishauser, Barbara ; Mayer, Michael

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 59–62

Pore-forming peptides are of interest due to their antimicrobial activity and ability to form gateways through lipid membranes. Chemical modification of these peptides makes it possible to arrange several peptide monomers into well-defined pore-forming structures using various templating strategies. These templated super-structures can exert antimicrobial activity at significantly lower total...