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Université de Fribourg

Does the single-item self-rated health measure the same thing across different wordings? Construct validity study

Cullati, Stéphane ; Bochatay, Naike ; Rossier, Clémentine ; Guessous, Idris ; Burton‑Jeangros, Claudine ; Courvoisier, Delphine S.

In: Quality of Life Research, 2020, p. -

The self-rated health (SRH) item is frequently used in health surveys but variations of its form (wording, response options) may hinder comparisons between versions over time or across surveys. The objectives were to determine (a) whether three SRH forms are equivalent, (b) the form with the best construct validity and (c) the best coding scheme to maximize equivalence across forms.

Université de Fribourg

Improving the assessment of communication competencies in a national licensing OSCE: lessons learned from an experts’ symposium

Monti, Matteo ; Klöckner-Cronauer, * , Christina ; Hautz, Stephanie C. ; Schnabel, Kai P. ; Breckwoldt, Jan ; Junod-Perron, Noëlle ; Feller, Sabine ; Bonvin, Raphael ; Huwendiek, Sören

In: BMC Medical Education, 2020, vol. 20, no. 1, p. 171

Background: As the communication competencies of physicians are crucial for providing optimal patient care, their assessment in the context of the high-stakes Objective Structured Clinical Examination (OSCE) is of paramount importance. Despite abundant literature on the topic, evidence-based recommendations for the assessment of communication competencies in high stakes OSCEs are scarce. As ...

Université de Fribourg

DNA origami as emerging technology for the engineering of fluorescent and plasmonic-based biosensors

Loretan, Morgane ; Domljanovic, Ivana ; Lakatos, Mathias ; Rüegg, Curzio ; Acuna, Guillermo P.

In: Materials, 2020, vol. 13, no. 9, p. 2185

DNA nanotechnology is a powerful and promising tool for the development of nanoscale devices for numerous and diverse applications. One of the greatest potential fields of application for DNA nanotechnology is in biomedicine, in particular biosensing. Thanks to the control over their size, shape, and fabrication, DNA origami represents a unique opportunity to assemble dynamic and complex...

Université de Fribourg

Allodynography: reliability of a new procedure for objective clinical examination of static mechanical allodynia

Packham, Tara L ; Spicher, Claude J ; Mac, Dermid, Joy C ; Buckley, Norman D

In: Pain Medicine, 2020, vol. 21, no. 1, p. 101–108

There is a need for reliable and valid clinical assessment tools for quantifying allodynia in neuropathic pain. Allodynography has been proposed as a useful standardized procedure for clinical assessment of mechanical allodynia. This study (www.clinicaltrials.gov NCT02070367) undertook preliminary investigation of the measurement properties of allodynography, a new standardized clinical ...

Médiathèque Valais

La grippe espagnole en Valais (1918-1919)

Marino, Laura ; Barras, Vincent (Dir.)

Thèse de doctorat : Médiathèque Valais, 2014.

Thèse. Biologie. Médecine. 2014.

Università della Svizzera italiana

Arl13b regulates breast cancer cell migration and invasion by controlling integrin-mediated signaling

Casalou, Cristina ; Faustino, Alexandra ; Silva, Fernanda ; Ferreira, Inês C. ; Vaqueirinho, Daniela ; Ferreira, Andreia ; Castanheira, Pedro ; Barona, Teresa ; Ramalho, José S. ; Serpa, Jacinta ; Félix, Ana ; Barral, Duarte C.

In: Cancers, 2019, vol. 11, no. 10, p. 1461

Breast cancer is the first cause of cancer-related mortality among women worldwide, according to the most recent estimates. This mortality is mainly caused by the tumors’ ability to form metastases. Cancer cell migration and invasion are essential for metastasis and rely on the interplay between actin cytoskeleton remodeling and cell adhesion. Therefore, understanding the mechanisms by which...

Università della Svizzera italiana

The novel TORC1/2 kinase inhibitor PQR620 has anti-tumor activity in lymphomas as a single agent and in combination with venetoclax

Tarantelli, Chiara ; Gaudio, Eugenio ; Hillmann, Petra ; Spriano, Filippo ; Sartori, Giulio ; Aresu, Luca ; Cascione, Luciano ; Rageot, Denise ; Kwee, Ivo ; Beaufils, Florent ; Zucca, Emanuele ; Stathis, Anastasios ; Wymann, Matthias P. ; Cmiljanovic, Vladimir ; Fabbro, Doriano ; Bertoni, Francesco

In: Cancers, 2019, vol. 11, no. 6, p. 775

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling cascade is an important therapeutic target for lymphomas. Rapamycin-derivates as allosteric mTOR complex 1 (TORC1) inhibitors have shown moderate preclinical and clinical anti-lymphoma activity. Here, we assessed the anti-tumor activity of PQR620, a novel brain penetrant dual TORC1/2 inhibitor, in 56...

Università della Svizzera italiana

Sedentary behaviour in Swiss children and adolescents : disentangling associations with the perceived and objectively measured environment

Bringolf-Isler, Bettina ; De Hoogh, Kees ; Schindler, Christian ; Kayser, Bengt ; Suggs, L. Suzanne ; Dössegger, Alain ; Probst-Hensch, Nicole ; The SOPHYA Study Group

In: International journal of environmental research and public health, 2018, vol. 15, no. 5, p. 918

Identifying correlates of sedentary behaviour across all levels of the ecological model and understanding their interrelations is a promising method to plan effective interventions. The present study examined whether the objectively assessed and the perceived neighbourhood are associated with children’s sedentary behaviour time (SBT). A comprehensive set of factors at different levels of...

Università della Svizzera italiana

The measurements and an elaborated understanding of Chinese eHealth literacy (C-eHEALS) in chronic patients in China

Chang, Angela ; Schulz, Peter J.

In: International journal of environmental research and public health, 2018, vol. 15, no. 7, p. 1553

The rapid rise of Internet-based technologies to disseminate health information and services has been shown to enhance online health information acquisition. A Chinese version of the electronic health literacy scale (C-eHEALS) was developed to measure patients’ combined knowledge and perceived skills at finding and applying electronic health information to health problems. A valid sample...