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Università della Svizzera italiana

The contribution of active and passive mechanisms of 5mC and 5hmC removal in human T lymphocytes is differentiation- and activation-dependent

Vincenzetti, Lucia ; Leoni, Cristina ; Chirichella, Michele ; Kwee, Ivo ; Monticelli, Silvia

In: European Journal of Immunology, 2019, p. 1-15

In mammals, the 5’-methylcytosine (5mC) modification in the genomic DNA contributes to the dynamic control of gene expression. 5mC erasure is required for the activation of developmental programs and occurs either by passive dilution through DNA replication, or by enzymatic oxidation of the methyl mark to 5-hydroxymethylcytosine (5hmC), which can persist as such or undergo further oxidation...

Università della Svizzera italiana

A selective ER‐phagy exerts procollagen quality control via a Calnexin‐FAM134B complex

Forrester, Alison ; Leonibus, Chiara De ; Grumati, Paolo ; Fasana, Elisa ; Piemontese, Marilina ; Staiano, Leopoldo ; Fregno, Ilaria ; Raimondi, Andrea ; Marazza, Alessandro ; Bruno, Gemma ; Iavazzo, Maria ; Intartaglia, Daniela ; Seczynska, Marta ; van Anken, Eelco ; Conte, Ivan ; De Matteis, Maria Antonietta ; Dikic, Ivan ; Molinari, Maurizio ; Settembre, Carmine

In: The EMBO Journal, 2019, vol. 38, no. 2, p. e99847

Autophagy is a cytosolic quality control process that recognizes substrates through receptor‐mediated mechanisms. Procollagens, the most abundant gene products in Metazoa, are synthesized in the endoplasmic reticulum (ER), and a fraction that fails to attain the native structure is cleared by autophagy. However, how autophagy selectively recognizes misfolded procollagens in the ER lumen is...

Università della Svizzera italiana

ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens

Proietti, Michele ; Perruzza, Lisa ; Scribano, Daniela ; Pellegrini, Giovanni ; D’Antuono, Rocco ; Strati, Francesco ; Raffaelli, Marco ; Gonzalez, Santiago F. ; Thelen, Marcus ; Hardt, Wolf-Dietrich ; Slack, Emma ; Nicoletti, Mauro ; Grassi, Fabio

In: Nature Communications, 2019, vol. 10, p. Art. number: 250

T cell dependent secretory IgA (SIgA) generated in the Peyer’s patches (PPs) of the small intestine shapes a broadly diverse microbiota that is crucial for host physiology. The mutualistic co-evolution of host and microbes led to the relative tolerance of host’s immune system towards commensal microorganisms. The ATP-gated ionotropic P2X7 receptor limits T follicular helper (Tfh) cells...

Université de Fribourg

A test of positive suggestions about side effects as a way of enhancing the analgesic response to NSAIDs

Fernandez, Aurore ; Kirsch, Irving ; Noël, Louis ; Rodondi, Pierre Yves ; Kaptchuk, Ted J. ; Suter, Marc R. ; Décosterd, Isabelle ; Berna, Chantal

In: PLOS ONE, 2019, vol. 14, no. 1, p. e0209851

Side effects are frequent in pharmacological pain management, potentially preceding analgesia and limiting drug tolerability. Discussing side effects is part of informed consent, yet can favor nocebo effects. This study aimed to test whether a positive suggestion regarding side effects, which could act as reminders of the medication having been absorbed, might favor analgesia in a clinical...

Università della Svizzera italiana

P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus

Faliti, Caterina E. ; Gualtierotti, Roberta ; Rottoli, Elsa ; Gerosa, Maria ; Perruzza, Lisa ; Romagnani, Andrea ; Pellegrini, Giovanni ; De Ponte Conti, Benedetta ; Rossi, Riccardo L. ; Idzko, Marco ; Mazza, Emilia M.C. ; Bicciato, Silvio ; Traggiai, Elisabetta ; Meroni, Pier Luigi ; Grassi, Fabio

In: Journal of Experimental Medicine, 2019, vol. 216, no. 2, p. 317-336

Altered control of T follicular helper (Tfh) cells can lead to generation of autoantibodies and autoimmune manifestations. Signaling pathways that selectively limit pathogenic responses without affecting the protective function of Tfh cells are unknown. Here we show that the ATP-gated ionotropic P2X7 receptor restricts the expansion of aberrant Tfh cells and the generation of self-reactive...

Université de Fribourg

Praxis und Institutionalisierung von Lebensende-Entscheidungen in der Schweiz. Beobachtungen aus sozialethischer Perspektive

In: Entscheidungen am Lebensende. Medizinethische und empirische Forschung im Dialog, 2016, p. 119–140

Université de Fribourg

Die Rationierungsdiskussion in der Schweiz. Beobachtungen aus ethischer Perspektive

Zimmermann-Acklin, Markus

In: DRG und Ethik. Ethische Auswirkungen von ökonomischen Steuerungselementen im Gesundheitswesen, 2011, p. 127–139

Université de Fribourg

Gesundheit. I. Sozialethisch

Zimmermann, Markus

In: Staatslexikon. Recht, Wirtschaft, Gesellschaft, 2018, vol. 2, p. 1278–1283

Université de Fribourg

Sterbehilfe und Palliative Care – Überlegungen aus ethischer Sicht

Zimmermann-Acklin, Markus

In: Innovative Palliative Care. Für eine neue Kultur der Pflege, Medizin und Betreuung, 2014, p. 80-92

Université de Fribourg

Von der Zweiklassenmedizin zur Zweiklassenpflege? Rationierung als pflegeethisches Problem

Zimmermann-Acklin, Markus

In: Handbuch Pflegeethik. Ethisch denken und handeln in den Praxisfeldern der Pflege, 2012, p. 202-215

Auf der Basis einiger Beispiele für pflegerische Leistungsbegrenzungen im Abschnitt 13.1 wird im Abschnitt 13.2 die bestehende Realität im pliziter bzw. ungeregelter Rationierung am Krankenbett als zentrale Problemstellung identifiziert. Aus Gerechtigkeitsgründen sollte die Fra ge im Mittelpunkt stehen, wie sich eine qualitativ hochstehende Ge sundheitsversorgung und Pflege für alle auf die...