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Università della Svizzera italiana

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

Markle, Janet G. ; Martínez-Barricarte, Rubén ; Ma, Cindy S. ; Deenick, Elissa K. ; Ramírez-Alejo, Noé ; Mele, Federico ; Latorre, Daniela ; Mahdaviani, Seyed Alireza ; Aytekin, Caner ; Mansouri, Davood ; Bryant, Vanessa L. ; Jabot-Hanin, Fabienne ; Deswarte, Caroline ; Nieto-Patlán, Alejandro ; Surace, Laura ; Kerner, Gaspard ; Itan, Yuval ; Jovic, Sandra ; Avery, Danielle T. ; Wong, Natalie ; Rao, Geetha ; Patin, Etienne ; Okada, Satoshi ; Bigio, Benedetta ; Boisson, Bertrand ; Rapaport, Franck ; Seeleuthner, Yoann ; Schmidt, Monika ; Ikinciogullari, Aydan ; Dogu, Figen ; Tanir, Gonul ; Tabarsi, Payam ; Bloursaz, Mohammed Reza ; Joseph, Julia K. ; Heer, Avneet ; Kong, Xiao-Fei ; Migaud, Mélanie ; Lazarov, Tomi ; Geissmann, Frédéric ; Fleckenstein, Bernhard ; Lindestam Arlehamn, Cecilia ; Sette, Alessandro ; Puel, Anne ; Emile, Jean-François ; Vosse, Esther van de ; Quintana-Murci, Lluis ; Di Santo, James P. ; Abel, Laurent ; Boisson-Dupuis, Stéphanie ; Bustamante, Jacinta ; Tangye, Stuart G. ; Sallusto, Federica ; Casanova, Jean-Laurent

In: Science Immunology, 2018, vol. 3, no. 30, p. eaau6759

Hundreds of patients with autosomal recessive, complete IL-12p40 or IL-12Rß1 deficiency have been diagnosed over the last 20 years. They typically suffer from invasive mycobacteriosis and, occasionally, from mucocutaneous candidiasis. Susceptibility to these infections is thought to be due to impairments of IL- 12–dependent IFN-? immunity and IL-23–dependent IL-17A/IL-17F immunity,...

Université de Fribourg

Transcutaneous aortic valve implantation using the carotid artery access: Feasibility and clinical outcomes

Kallinikou, Zacharenia ; Berger, Alexandre ; Ruchat, Patrick ; Khatchatourov, Gregory ; Fleisch, Isabelle ; Korkodelovic, Branislav ; Henchoz, Emmanuel ; Marti, René-Andréas ; Cook, Stéphane ; Togni, Mario ; Goy, Jean-Jacques

In: Archives of Cardiovascular Diseases, 2017, vol. 110, no. 6, p. 389–394

Background: Transcarotid access is an alternative route for transcutaneous aortic valve implantation (TAVI) in patients with impossible transfemoral access.Aims: We evaluated the safety, effectiveness and early and late clinical outcomes of CoreValve® implantation via the common carotid artery.Methods: Eighteen patients (10 men, 8 women; mean age 84 ± 5 years) at high surgical risk (mean...

Université de Fribourg

Clinical follow-up of the first SF-1 insufficient female patient = Suivi de la première patiente atteinte d’une insuffisance de SF-1

Gerster, Karine ; Biason-Lauber, Anna ; Schoenle, Eugen J.

In: Annales d’Endocrinologie, 2017, vol. 78, no. 3, p. 156–161

Steroidogenic factor 1 (SF-1/NR5A1) plays a crucial role in regulating adrenal development, gonad determination and differentiation, and in the hypothalamic-pituitary control of reproduction and metabolism. In men (46, XY), it is known that mutations in SF-1/NR5A1 gene cause a wide phenotypic spectrum with variable degrees of undervirilization. In recent years, the role of SF-1 in the ovarian...

Université de Fribourg

Late thrombotic events after bioresorbable scaffold implantation: a systematic review and meta-analysis of randomized clinical trials

Collet, Carlos ; Asano, Taku ; Miyazaki, Yosuke ; Tenekecioglu, Erhan ; Katagiri, Yuki ; Sotomi, Yohei ; Cavalcante, Rafael ; Winter, Robbert J. de ; Kimura, Takeshi ; Gao, Runlin ; Puricel, Serban ; Cook, Stéphane ; Capodanno, Davide ; Onuma, Yoshinobu ; Serruys, PatrickW.

In: European Heart Journal, 2017, p. -

To compare the long-term safety and efficacy of bioresorbable vascular scaffold (BVS) with everolimus-eluting stent (EES) after percutaneous coronary interventions.Methods and Results: A systematic review and meta-analysis of randomized clinical trials comparing clinical outcomes of patients treated with BVS and EES with at least 24 months follow-up was performed. Adjusted random-effect model...

Université de Fribourg

Heart rate never lies: interventional cardiologist and Braude’s quote revised

Cook, Stéphane ; Stauffer, Jean-Christophe ; Goy, Jean-Jacques ; Graf, Denis ; Puricel, Serban ; Frobert, Aurélien ; Muller, Olivier ; Togni, Mario ; Arroyo, Diego

In: Open Heart, 2016, vol. 3, no. 1, p. e000373

Background Interventional cardiologists may be immune to stress, allowing them to perform complex percutaneous interventions under pressure.Objectives To assess heart rate (HR) variations as a surrogate marker of stress of interventional cardiologists during percutaneous cardiac procedures and in every-day life.Design This is a single-centre...

Université de Fribourg

Bioresorbable coronary scaffold thrombosis: multicenter comprehensive analysis of clinical presentation, mechanisms, and predictors

Puricel, Serban ; Cuculi, Florim ; Weissner, Melissa ; Schmermun, Axel ; Jamshidi, Peiman ; Nyffenegger, Tobias ; Binder, Harald ; Eggebrecht, Holger ; Münzel, Thomas ; Cook, Stephane ; Gori, Tommaso

In: Journal of the American College of Cardiology, 2016, vol. 67, no. 8, p. 921–931

Background Recent reports suggest an elevated incidence of bioresorbable vascular scaffold (BVS) thrombosis (scaffold thrombosis [ScT]).Objectives This study investigated occurrence rates, clinical and angiographic characteristics, and possible mechanisms of ScT in all-comer patients undergoing BVS implantation at 2 German and 2 Swiss hospitals.Methods A total of 1,305 consecutive patients (mean...

Université de Fribourg

Preventing implant-associated infections by silver coating

Kuehl, Richard ; Brunetto, Priscilla S. ; Woischnig, Anne-Kathrin ; Varisco, Massimo ; Rajacic, Zarko ; Vosbeck, Juerg ; Terracciano, Luigi ; Fromm, Katharina M. ; Khanna, Nina

In: Antimicrobial Agents and Chemotherapy, 2016, p. AAC.02934–15

Implant-associated infections (IAI) are a dreaded complication mainly caused by biofilm-forming staphylococci. Implant surfaces preventing microbial colonization would be desirable. We examined the preventive effect of a silver-coated titanium aluminium niobium (TiAlNb) alloy. The surface elicited a strong, inoculum-dependent activity against Staphylococcus (S.) epidermidis and S. aureus in an...

Université de Fribourg

About the usefulness of contact precautions for carriers of extended-spectrum beta-lactamase-producing Escherichia coli

Zahar, Jean-Ralph ; Poirel, Laurent ; Dupont, Claire ; Fortineau, Nicolas ; Nassif, Xavier ; Nordmann, Patrice

In: BMC Infectious Diseases, 2015, vol. 15, p. 512

Extended-spectrum β-lactamases producing Escherichia coli (ESBL-E) are increasingly identified in health care facilities. As previously done for the control of methicillin-resistant Staphylococcus aureus, many hospitals have established screening strategies for early identification of patients being carriers of ESBL producers in general and ESBL-E in particular, and have implemented contact...

Université de Fribourg

Comparison of a novel biodegradable polymer sirolimus-eluting stent With a durable polymer everolimus-eluting stent results of the randomized BIOFLOW-II trial

Windecker, Stephan ; Haude, Michael ; Neumann, Franz-Josef ; Stangl, karl ; Witzenbichler, Bernhard ; Slagboom, Ton ; Sabaté, Manel ; Goicolea, Javier ; Barragan, Paul ; Cook, Stéphane ; Piot, Christophe ; Richardt, Gert ; Merkely, Béla ; Schneider, Henrik ; Bilger, Johannes ; Erne, Paul ; Waksman, Ron ; Zaugg, Serge ; Jüni, Peter ; Lefèvre, Thierry

In: Circulation: Cardiovascular Interventions, 2015, vol. 8, no. 2, p. e001441

Background—Biodegradable polymers for release of antiproliferative drugs from drug-eluting stents aim to improve vascular healing. We assessed noninferiority of a novel ultrathin strut drug-eluting stent releasing sirolimus from a biodegradable polymer (Orsiro, O-SES) compared with the durable polymer Xience Prime everolimus-eluting stent (X-EES) in terms of the primary end...