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Università della Svizzera italiana

Expression of CXCL12 receptors in B cells from Mexican Mestizos patients with systemic lupus erythematosus

Biajoux, Vincent ; Bignon, Alexandre ; Freitas, Christelle ; Martinez, Valérie ; Thelen, Marcus ; Lima, Guadalupe ; Jakez-Ocampo, Juan ; Emilie, Dominique ; Llorente, Luis ; Balabanian, Karl

In: Journal of translational medicine, 2012, vol. 10, no. 1, p. 251-267

Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by B-cell hyperreactivity and the production of pathogenic anti-nuclear- directed auto-antibodies (Abs). B-cell ontogeny is partly dependent on the CXCL12/CXCR4 axis for which the contribution to SLE pathogenesis remains unclear. CXCR7, the novel receptor for CXCL12, is differentially expressed among...

Università della Svizzera italiana

Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface

Di Zenzo, Giovanni ; Di Lullo, Giulia ; Corti, Davide ; Calabresi, Valentina ; Sinistro, Anna ; Vanzetta, Fabrizia ; Didona, Biagio ; Cianchini, Giuseppe ; Hertl, Michael ; Eming, Rudiger ; Amagai, Masayuki ; Ohyama, Bungo ; Hashimoto, Takashi ; Sloostra, Jerry ; Sallusto, Federica ; Zambruno, Giovanna ; Lanzavecchia, Antonio

In: The journal of clinical investigation, 2012, vol. 122, no. 10, p. 3781-3790

Pemphigus vulgaris (PV) is an autoimmune blistering disease of skin and mucous membranes caused by autoantibodies to the desmoglein (DSG) family proteins DSG3 and DSG1, leading to loss of keratinocyte cell adhesion. To learn more about pathogenic PV autoantibodies, we isolated 15 IgG antibodies specific for DSG3 from 2 PV patients. Three antibodies disrupted keratinocyte monolayers in vitro,...

Università della Svizzera italiana

CCR2 acts as scavenger for CCL2 during monocyte chemotaxis

Volpe, Silvia ; Cameroni, Elisabetta ; Moepps, Barbara ; Thelen, Sylvia ; Apuzzo, Tiziana ; Thelen, Marcus

In: Plos one, 2012, vol. 7, no. 5, p. e37208

Background: Leukocyte migration is essential for effective host defense against invading pathogens and during immune homeostasis. A hallmark of the regulation of this process is the presentation of chemokines in gradients stimulating leukocyte chemotaxis via cognate chemokine receptors. For efficient migration, receptor responsiveness must be maintained whilst the cells crawl on cell surfaces...

Università della Svizzera italiana

Immunogenetic mechanisms driving norovirus GII.4 antigenic variation

Lindesmith, Lisa C. ; Beltramello, Martina ; Donaldson, Eric F. ; Corti, Davide ; Swanstrom, Jesica ; Debbink, Kari ; Lanzavecchia, Antonio ; Baric, Ralph S.

In: Plos pathogens, 2012, vol. 8, no. 5, p. e1002705

Noroviruses are the principal cause of epidemic gastroenteritis worldwide with GII.4 strains accounting for 80% of infections. The major capsid protein of GII.4 strains is evolving rapidly, resulting in new epidemic strains with altered antigenic potentials. To test if antigenic drift may contribute to GII.4 persistence, human memory B cells were immortalized and the resulting human monoclonal...

Università della Svizzera italiana

Microclimates and the city : towards an architectural theory of thermal diversity

Roesler, Sascha ; Kobi, Madlen

In: The urban microclimate as artifact : towards an architectural theory of thermal diversity, 2018, p. 12-24

The term “microclimate” was coined by German and British meteorologists and geographers in the first half of the 20th century. Rudolf Geiger and Albert Kratzer realized that the climate in the air layer “two meters above the ground” differs considerably between rural and urban sites. W.G.V. Balchin and Norman Pye proved that the urban climate within one city, Bath, was not homogenous,...

Università della Svizzera italiana

Systems analysis of MVA-C induced immune response reveals its significance as a vaccine candidate against HIV/AIDS of clade C

Gómez, Carmen Elena ; Perdiguero, Beatriz ; Jiménez, Victoria ; Filali-Mouhim, Abdelali ; Ghneim, Khader ; Haddad, Elias K. ; Quakkerlaar, Esther D. ; Delaloye, Julie ; Harari, Alexandre ; Roger, Thierry ; Dunhen, Thomas ; Sékaly, Rafick P. ; Melief, Cornelis J. M. ; Calandra, Thierry ; Sallusto, Federica ; Lanzavecchia, Antonio ; Wagner, Ralf ; Pantaleo, Giuseppe ; Esteban, Mariano

In: Plos one, 2012, vol. 7, no. 4, p. e35485

Based on the partial efficacy of the HIV/AIDS Thai trial (RV144) with a canarypox vector prime and protein boost, attenuated poxvirus recombinants expressing HIV-1 antigens are increasingly sought as vaccine candidates against HIV/AIDS. Here we describe using systems analysis the biological and immunological characteristics of the attenuated vaccinia virus Ankara strain expressing the HIV-1...

Università della Svizzera italiana

Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses

Viejo-Borbolla, Abel ; Martinez-Martín, Nadia ; Nel, Hendrik J. ; Rueda, Patricia ; Martín, Rocío ; Blanco, Soledad ; Arenzana-Seisdedos, Fernando ; Thelen, Marcus ; Fallon, Padraic G. ; Alcamí, Antonio

In: Plos pathogens, 2012, vol. 8, no. 2, p. e1002497

Herpes simplex virus (HSV) types 1 and 2 are highly prevalent human neurotropic pathogens that cause a variety of diseases, including lethal encephalitis. The relationship between HSV and the host immune system is one of the main determinants of the infection outcome. Chemokines play relevant roles in antiviral response and immunopathology, but the modulation of chemokine function by HSV is...

Università della Svizzera italiana

Characterization of variable regions of the Gp120 protein from HIV-1 subtype C virus variants obtained from individuals at different disease stages in Sub-Saharan Africa

Cenci, A. ; Tavoschi, L. ; D'Avenio, G. ; Narino, P. ; Becattini, S. ; Bernasconi, D. ; Chiappi, M. ; La Torre, L. ; Sukati, H. ; Vardas, E. ; Lo Presti, A. ; Cella, E. ; Ciccozzi, M. ; Picconi, O. ; Monini, P. ; Ensoli, B. ; Buttò, S.

In: Journal of AIDS & clinical research, 2012, vol. S8:006, p. 1-10

Background: The development of a vaccine against HIV/AIDS capable of preventing virus infection has been hampered by the HIV envelope (Env) heterogeneity that makes it difficult to induce neutralizing antibodies against Env proteins from different HIV clades. Several studies have indicated that gp120 Env protein sequence tends to change considerably during the course of HIV disease which...

Università della Svizzera italiana

MiR-146a in immunity and disease

Rusca, Nicole ; Monticelli, Silvia

In: Molecular biology international, 2011, vol. 2011, p. 1-7

MicroRNAs (miRNAs) are regulatory molecules able to influence all aspects of the biology of a cell. They have been associated with diseases such as cancer, viral infections, and autoimmune diseases, and in recent years, they also emerged as important regulators of immune responses. MiR-146a in particular is rapidly gaining importance as a modulator of differentiation and function of cells of...