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Université de Fribourg

Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis

Tiam, Eric Robert ; Ngono Bikobo, Dominique Serge ; Zintchem, Auguste Abouem A. ; Mbabi Nyemeck II, Norbert ; Moni Ndedi, Esther Del Florence ; Betote Diboué, Patrick Hervé ; Nyegue, Maximilienne Ascension ; Atchadé, Alex de Théodore ; Pegnyemb, Dieudonné Emmanuel ; Bochet, Christian G. ; Koert, Ulrich

In: Natural Product Research, 2019, vol. 33, no. 5, p. 642–650

Triclisinone (2), a new ochnaflavone derivative, was isolated from the aerial parts of Triclisia gilletii, along with known drypemolundein B (1) and eight other known compounds. The chemical shifts of drypemolundein B (1) have been partially revised based on reinterpretation of NMR spectroscopic data. The eight other secondary metabolites are composed of: (+)-nonacosan-10-ol (3); stigmasterol...

Université de Fribourg

Modification of sperm fatty acid composition during epididymal maturation in bats

Fasel, Nicolas J. ; McMillian, Kevin ; Jakop, Ulrike ; Méné-Saffrané, Laurent ; Engel, Kathrin M. ; Genoud, Michel ; Müller, Karin ; Christe, Philippe

In: Reproduction, 2019, vol. 157, no. 1, p. 77–85

Biochemical properties of polyunsaturated fatty acids (PUFAs) are fundamental to sperm movements. Amongst all adjustments operated during epididymal maturation, sperm membrane lipid composition is remodelled. Specifically, the proportion of PUFAs usually increases from the caput towards the cauda epididymidis. In mammals, PUFAs are predominantly acquired through the diet, which can ...

Haute Ecole d'Ingénierie

Installation d’instrument par drone (InstalloDrone)

Gillioz, Loïc ; Moerschell, Joseph (Dir.)

Mémoire de bachelor : Haute Ecole d'Ingénierie, 2018.

Les instruments de mesure environnementaux doivent souvent être installés dans des zones à risque. Ce projet cherche à développer un concept d'installation d'un appareil sur un rocher, avec un drone, pour réduire les risques et les coûts.

Université de Neuchâtel

Semantic content in titi monkey alarm call sequences

Berthet, Mélissa ; Zuberbühler, Klaus (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

The comparative approach aims to understand the uniqueness of human language and how it evolved from primitive communication systems. Black-fronted titi monkeys Callicebus nigrifrons possess two soft alarm calls: A-calls are specific to threats within the canopy while B-calls are general calls emitted to terrestrial predators but also in non-predatory contexts, while moving near the...

Haute Ecole d'Ingénierie

3D profile reconstruction

Briguet, Daniel ; Kandaswamy, Djano (Dir.)

Mémoire de bachelor : Haute Ecole d'Ingénierie, 2018.

The objective of the project is to develop a system to reconstruct in 3D the profile of a moving object.

Haute Ecole d'Ingénierie

Détection de victimes d’avalanches par drone

Bontempelli, Vincent ; Roduit, Pierre (Dir.)

Mémoire de bachelor : Haute Ecole d'Ingénierie, 2018.

Le but de ce projet est de déterminer les possibilités et l’efficacité de l’utilisation d’un drone lors d’une recherche de victimes avalanches.

Université de Fribourg

A spatially and functionally distinct pool of TORC1 defines signaling endosomes in yeast

Hatakeyama, Riko ; De Virgilio, Claudio

In: Autophagy, 2019, vol. 15, no. 5, p. 915–916

The evolutionarily conserved target of rapamycin complex 1 (TORC1) regulates cell growth in a homeostatic manner by tuning anabolic and catabolic processes in response to nutritional and hormonal cues. Interestingly, rather than being localized at the plasma membrane as perhaps expected for an integrator of extracellular signals, TORC1 mainly localizes at vacuolar (in yeast) and lysosomal (in...

Université de Fribourg

An atomistic look into bio-inspired nanoparticles and their molecular interactions with cells

Petretto, Emanuele ; Campomanes, Pablo ; Stellacci, Francesco ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke ; Vanni, Stefano

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 78–80

Nanoparticles (NPs) have sizes that approach those of pathogens and they can interact with the membranes of eukaryotic cells in an analogous fashion. Typically, NPs are taken up by the cell via the plasma membrane by receptor-mediated processes and subsequently interact with various endomembranes. Unlike pathogens, however, NPs lack the remarkable specificity gained during the evolutionary...

Université de Fribourg

Templated assembly of pore-forming peptides in lipid membranes

Fennouri, Aziz ; List, Jonathan ; Dupasquier, Jessica ; Haeni, Laetitia ; Vanni, Stefano ; Rothen-Rutishauser, Barbara ; Mayer, Michael

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 59–62

Pore-forming peptides are of interest due to their antimicrobial activity and ability to form gateways through lipid membranes. Chemical modification of these peptides makes it possible to arrange several peptide monomers into well-defined pore-forming structures using various templating strategies. These templated super-structures can exert antimicrobial activity at significantly lower total...

Université de Fribourg

Valuable carcasses: postmortem preservation of fatty acid composition in heart tissue

Currie, Shannon E. ; Mène-Saffrané, Laurent ; Fasel, Nicolas J.

In: Conservation Physiology, 2019, vol. 7, no. 1, p. -

In order to effectively conserve species, we must understand the structure and function of integral mechanisms at all levels of organismal organisation, from intracellular biochemistry to whole animal ecophysiology. The accuracy of biochemical analyses depend on the quality and integrity of the samples analysed. It is believed that tissue samples collected immediately postmortem provide the...