No exact match found for Schwab M.E, using Schwab M E instead...
Université de Fribourg

Influence of anti-Nogo-A antibody treatment on the reorganization of callosal connectivity of the premotor cortical areas following unilateral lesion of primary motor cortex (M1) in adult macaque monkeys

Hamadjida, Adjia ; Wyss, Alexander F. ; Mir, Anis ; Schwab, Martin E. ; Belhaj-Saif, Abderaouf ; Rouiller, Eric M.

In: Experimental Brain Research, 2012, vol. 223, no. 3, p. 321-340

Following unilateral lesion of the primary motor cortex, the reorganization of callosal projections from the intact hemisphere to the ipsilesional premotor cortex (PM) was investigated in 7 adult macaque monkeys, in absence of treatment (control; n = 4) or treated with function blocking antibodies against the neurite growth inhibitory protein Nogo-A (n = 3). After functional recovery, though...

Université de Fribourg

Invasion of lesion territory by regenerating fibers after spinal cord injury in adult macaque monkeys

Beaud, Marie-Laure ; Rouiller, Eric M. ; Bloch, Jocelyne ; Mir, Anis ; Schwab, M.E. ; Wannier, Thierry ; Schmidlin, Eric

In: Neuroscience, 2012, vol. 27, p. 271–282

In adult macaque monkeys subjected to an incomplete spinal cord injury (SCI), corticospinal (CS) fibers are rarely observed to grow in the lesion territory. This situation is little affected by the application of an anti-Nogo-A antibody which otherwise fosters the growth of CS fibers rostrally and caudally to the lesion. However, when using the Sternberger monoclonal-incorporated antibody 32...

Université de Fribourg

Anti-Nogo-A antibody treatment promotes recovery of manual dexterity after unilateral cervical lesion in adult primates – re-examination and extension of behavioral data

Freund, Patrick ; Schmidlin, Eric ; Wannier, Thierry ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E. ; Rouiller, Eric M.

In: European Journal of Neuroscience, 2009, vol. 29, no. 5, p. 983 - 996

In rodents and nonhuman primates subjected to spinal cord lesion, neutralizing the neurite growth inhibitor Nogo-A has been shown to promote regenerative axonal sprouting and functional recovery. The goal of the present report was to re-examine the data on the recovery of the primate manual dexterity using refined behavioral analyses and further statistical assessments, representing secondary...

Université de Fribourg

Fate of rubrospinal neurons after unilateral section of the cervical spinal cord in adult macaque monkeys: Effects of an antibody treatment neutralizing Nogo-A

Wannier-Morino, Patrizia ; Schmidlin, Eric ; Freund, Patrick ; Belhaj-Saif, Abderraouf ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E. ; Rouiller, Eric M. ; Wannier, Tierry

In: Brain Research, 2008, vol. 1217, p. 96-109

The present study describes in primates the effects of a spinal cord injury on the number and size of the neurons in the magnocellular part of the red nucleus (RNm), the origin of the rubrospinal tract, and evaluates whether a neutralization of Nogo-A reduces the lesioned-induced degenerative processes observed in RNm. Two groups of monkeys were subjected to unilateral section of the spinal cord...

Université de Fribourg

Anti-Nogo-A antibody treatment does not prevent cell body shrinkage in the motor cortex in adult monkeys subjected to unilateral cervical cord lesion

Beaud, Marie-Laure ; Schmidlin, Eric ; Wannier, Thierry ; Freund, Patrick ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E. ; Rouiller, Eric M.

Background: After unilateral cervical cord lesion at the C7/C8 border interrupting the dorsolateral funiculus in adult monkeys, neutralization of Nogo-A using a specific monoclonal antibody promoted sprouting of corticospinal (CS) axons rostral and caudal to the lesion and, in parallel, improved functional recovery. In monkeys lesioned but not treated with the anti-Nogo-A antibody, the CS neurons...

Université de Fribourg

Repair of the injured spinal cord, a joint approach of basic and clinical research

Buchli, Anita D. ; Rouiller, Eric M. ; Mueller, Roland ; Dietz, Volker ; Schwab, Martin E.

In: Neurodegenerative Diseases, 2007, vol. 4, no. 1, p. 51-56

The myelin protein Nogo-A is a potent inhibitor of neurite outgrowth in the central nervous system, thus contributing to the incapacity of fiber tracts in the adult spinal cord to regenerate after injury. In this review we report on a joint approach of different research groups to develop a therapy applying anti-Nogo-A antibodies to the injured spinal cord. While basic researchers took the...

Université de Fribourg

Anti-Nogo-A antibody treatment enhances sprouting of corticospinal axons rostral to a unilateral cervical spinal cord lesion in adult macaque monkey

Freund, Patrick ; Wannier, Thierry ; Schmidlin, Eric ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E. ; Rouiller, Eric M.

In: The Journal of Comparative Neurology, 2007, vol. 502, no. 4, p. 644 - 659

After injury, regrowth of axons in mammalian adult central nervous system is highly limited. However, in monkeys subjected to unilateral cervical lesion (C7-C8 level), neutralization of an important neurite outgrowth inhibitor, Nogo-A, stimulated axonal sprouting caudal to the lesion, accompanied by enhanced functional recovery of manual dexterity, compared with lesioned monkeys treated with a...

Université de Fribourg

Nogo-A–specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates

Freund, Patrick ; Schmidlin, Eric ; Wannier, Thierry ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E ; Rouiller, Eric M

In: Nature Medicine, 2006/12/

In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A–specific antibody as compared to monkeys treated with control...