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Université de Fribourg

Diesel exhaust: current knowledge of adverse effects and underlying cellular mechanisms

Steiner, Sandro ; Bisig, Christoph ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Archives of Toxicology, 2016, p. 1–13

Diesel engine emissions are among the most prevalent anthropogenic pollutants worldwide, and with the growing popularity of diesel-fueled engines in the private transportation sector, they are becoming increasingly widespread in densely populated urban regions. However, a large number of toxicological studies clearly show that diesel engine emissions profoundly affect human health. Thus the...

Université de Fribourg

Engineered nanomaterials: toward effective safety management in research laboratories

Groso, Amela ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Hofmann, Heinrich ; Meyer, Thierry

In: Journal of Nanobiotechnology, 2016, vol. 14, p. 21

It is still unknown which types of nanomaterials and associated doses represent an actual danger to humans and environment. Meanwhile, there is consensus on applying the precautionary principle to these novel materials until more information is available. To deal with the rapid evolution of research, including the fast turnover of collaborators, a user-friendly and easy-to-apply risk...

Université de Fribourg

Plasmonic nanoparticles and their characterization in physiological fluids

Urban, Dominic A. ; Rodriguez-Lorenzo, Laura ; Balog, Sandor ; Kinnear, Calum ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Colloids and Surfaces B: Biointerfaces, 2016, vol. 137, p. 39–49

Nanoparticles possess unique properties beyond that of classical materials, and while these properties can be used for designing a dedicated functionality, they may also pose a problem to living organisms, to human health and the environment. The specific primary routes by which nanoparticles may interact with the human body include inhalation, injection, ingestion and application to the skin....

Université de Fribourg

Distribution of silica-coated silver/gold nanostars in soft- and hardwood applying SERS-based imaging

Geers, Christoph ; Rodríguez-Lorenzo, Laura ; Placencia Peña, M. I. ; Brodard, Pierre ; Volkmer, T. ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Langmuir, 2016, vol. 32, no. 1, p. 274–283

Nanoparticles (NPs) in aqueous suspension have just begun to be exploited for the preservative treatment of wood. However, at present, there is very little information available on the distribution of NPs in wood after impregnation, due to associated analytical challenges. In this study, we present the detection of model NPs in softwood and hardwood by surface-enhanced Raman spectroscopy (SERS)....

Université de Fribourg

Synthesis, characterization, antibacterial activity and cytotoxicity of hollow /TiO₂-coated CeO₂ nanocontainers encapsulating silver nanoparticles for controlled silver release

Gagnon, Jacinthe ; Clift, Martin J. D. ; Vanhecke, Dimitri ; Widnersson, I. E. ; Abram, S.-L. ; Petri-Fink, Alke ; Caruso, R. A. ; Rothen-Rutishauser, Barbara ; Fromm, Katharina M.

In: Journal of Materials Chemistry B, 2016, vol. 4, no. 6, p. 1166–1174

Biomaterials as implants are being applied more extensively in medicine due to their on-going development and associated improvements, and the increase in human life expectancy. Nonetheless, biomaterial-related infections, as well as propagating bacterial resistance, remain significant issues. Therefore, there is a growing interest for silver-based drugs because of their efficient and broad-range...

Université de Fribourg

Formation of drug nanocrystals under nanoconfinement afforded by liposomes

Cipolla, D. ; Wu, H. ; Salentinig, S. ; Boyd, B. ; Rades, T. ; Vanhecke, Dimitri ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Eastman, S. ; Redelmeier, T. ; Gonda, I. ; Chan, H. K.

In: RSC Advances, 2016, vol. 6, no. 8, p. 6223–6233

Nanocrystals of drug substances have important therapeutic applications, but their preparation is often difficult due to size control in bottom up approaches, or energetic milling and surface activation in top down processing. In this study, confinement within liposome nanocompartments is demonstrated to enable drug crystallization with a high aspect ratio but limited growth resulting in...

Université de Fribourg

Biological effects in lung cells In vitro of exhaust aerosols from a gasoline passenger car with and without particle filter

Bisig, Christoph ; Steiner, Sandro ; Comte, Pierre ; Czerwinski, Jan ; Mayer, Andreas ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Emission Control Science and Technology, 2015, vol. 1, no. 3, p. 237–246

Exhaust aerosol from gasoline passenger cars is a complex mixture of a particulate fraction as well as volatile compounds. In contrary to the observed adverse effects of diesel exhaust particles the gasoline exhaust has, however, received little attention so far. The aim of this study was to perform a comparison of exhaust composition and biological responses from freshly produced non-filtered...

Université de Fribourg

Ultrathin ceramic membranes as scaffolds for functional cell coculture models on a biomimetic scale

Jud, Corinne ; Ahmed, Sher ; Müller, Loretta ; Kinnear, Calum ; Vanhecke, Dimitri ; Umehara, Yuki ; Frey, Sabine ; Liley, Martha ; Angeloni, Silvia ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: BioResearch Open Access, 2015, vol. 4, no. 1, p. 457–468

Epithelial tissue serves as an interface between biological compartments. Many in vitro epithelial cell models have been developed as an alternative to animal experiments to answer a range of research questions. These in vitro models are grown on permeable two-chamber systems; however, commercially available, polymer-based cell culture inserts are around 10 μm thick. Since the basement...

Université de Fribourg

Translocation of gold nanoparticles across the lung epithelial tissue barrier: Combining in vitro and in silico methods to substitute in vivo experiments

Bachler, Gerald ; Losert, Sabrina ; Umehara, Yuki ; Goetz, Natalie von ; Rodriguez-Lorenzo, Laura ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Hungerbuehler, Konrad

In: Particle and Fibre Toxicology, 2015, vol. 12, no. 1, p. 18

The lung epithelial tissue barrier represents the main portal for entry of inhaled nanoparticles (NPs) into the systemic circulation. Thus great efforts are currently being made to determine adverse health effects associated with inhalation of NPs. However, to date very little is known about factors that determine the pulmonary translocation of NPs and their subsequent distribution to secondary...