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Public access from Oct 14, 2014
Université de Fribourg

In Vitro dosimetry of agglomerates

Hirsch, Vera ; Kinnear, Calum ; Rodriguez-Lorenzo, Laura ; Monnier, Christophe A. ; Rothen-Rutishauser, Barbara ; Balog, Sandor ; Petri-Fink, Alke

In: Nanoscale, 2014, p. -

Agglomeration of nanoparticles in biological fluids is a pervasive phenomenon that leads to difficulty in the interpretation of results from in vitro exposures, primarily due to the differing particokinetics of agglomerates to nanoparticles. Therefore, well-defined small agglomerates were designed that possessed different particokinetics profiles, and their cellular uptake was compared to a...

Public access from Oct 14, 2014
Université de Fribourg

Test-methods on the test-bench: a comparison of complete exhaust and exhaust particle extracts for genotoxicity/mutagenicity assessment

Steiner, Sandro ; Heeb, Norbert V. ; Czerwinski, Jan ; Comte, Pierre ; Mayer, Andreas ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Environmental Science & Technology, 2014, vol. 48, no. 9, p. 5237–5244

With the growing number of new exhaust after-treatment systems, fuels and fuel additives for internal combustion engines, efficient and reliable methods for detecting exhaust genotoxicity and mutagenicity are needed to avoid the widespread application of technologies with undesirable effects toward public health. In a commonly used approach, organic extracts of particulates rather than complete...

Université de Fribourg

Modeling nanoparticle–alveolar epithelial cell interactions under breathing conditions using captive bubble surfactometry

Schürch, David ; Vanhecke, Dimitri ; Clift, Martin J. D. ; Raemy, David ; Aberasturi, Dorleta Jimenez de ; Parak, Wolfgang J. ; Gehr, Peter ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Langmuir, 2014, vol. 30, no. 17, p. 4924–4932

Many advances have been made in recent years in cell culture models of the epithelial barrier of the lung from simple monolayers to complex 3-D systems employing different cell types. However, the vast majority of these models still present a static air–liquid interface which is unrealistic given the dynamic nature of breathing. We present here a method where epithelial lung cells are...

Public access from Oct 10, 2014
Université de Fribourg

Magnetic microreactors for efficient and reliable magnetic nanoparticle surface functionalization

Digigow, Reinaldo G. ; Dechézelles, Jean-François ; Kaufmann, J. ; Vanhecke, Dimitri ; Knapp, H. ; Lattuada, Marco ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Lab on a Chip, 2014, p. -

Microreactors have attracted wide attention in the nano- and biotechnology fields because they offer many advantages over standard liquid phase reactions. We report the development of a magnetic microreactor for reliable, fast and efficient surface functionalization of superparamagnetic iron oxide nanoparticles (SPIONs). A comprehensive study of the development process in terms of setup, loading...

Public access from Oct 10, 2014
Université de Fribourg

Insertion of Nanoparticle Clusters into Vesicle Bilayers

Bonnaud, Cécile ; Monnier, Christophe A. ; Demurtas, Davide ; Jud, Corinne ; Vanhecke, Dimitri ; Xavier Montet ; Ruud Hovius ; Lattuada, Marco ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: ACS Nano, 2014, vol. 8, no. 4, p. 3451–3460

A major contemporary concern in developing effective liposome–nanoparticle hybrids is the present inclusion size limitation of nanoparticles between vesicle bilayers, which is considered to be around 6.5 nm in diameter. In this article, we present experimental observations backed by theoretical considerations which show that greater structures can be incorporated within vesicle membranes by...

Université de Fribourg

Reduction in (pro-)inflammatory responses of lung cells exposed in vitro to diesel exhaust treated with a non-catalyzed diesel particle filter

Steiner, Sandro ; Czerwinski, Jan ; Comte, Pierre ; Müller, Loretta L. ; Heeb, Norbert V. ; Mayer, Andreas ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Atmospheric Environment, 2013, vol. 81, p. 117–124

Increasingly stringent regulation of particulate matter emissions from diesel vehicles has led to the widespread use of diesel particle filters (DPFs), the effect of which on exhaust toxicity is so far poorly understood. We exposed a cellular model of the human respiratory epithelium at the air-liquid interface to non-catalyzed wall-flow DPF-filtered diesel exhaust and compared the resulting...

Public access from Aug 18, 2014
Université de Fribourg

Fluorescence-encoded gold nanoparticles: library design and modulation of cellular uptake into dendritic cells

Rodriguez-Lorenzo, Laura ; Fytianos, Kleanthis ; Blank, Fabian ; Garnier, Christophe von ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Small, 2014, vol. 10, no. 7, p. 1341–1350

In order to harness the unique properties of nanoparticles for novel clinical applications and to modulate their uptake into specific immune cells we designed a new library of homo- and hetero-functional fluorescence-encoded gold nanoparticles (Au-NPs) using different poly(vinyl alcohol) and poly(ethylene glycol)-based polymers for particle coating and stabilization. The encoded particles were...

Public access from Aug 18, 2014
Université de Fribourg

A comparative study of different in vitro lung cell culture systems to assess the most beneficial tool for screening the potential adverse effects of carbon nanotubes

Clift, Martin J. D. ; Endes, Carola ; Vanhecke, Dimitri ; Wick, Peter ; Gehr, Peter ; Schins, Roel P. F. ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Toxicological Sciences, 2014, vol. 137, no. 1, p. 55–64

To determine the potential inhalatory risk posed by carbon nanotubes (CNTs), a tier-based approach beginning with an in vitro assessment must be adopted. The purpose of this study therefore was to compare 4 commonly used in vitro systems of the human lung (human blood monocyte-derived macrophages [MDM] and monocyte-derived dendritic cells [MDDC], 16HBE14o- epithelial cells, and...

Université de Fribourg

Can the Ames test provide an insight into nano-object mutagenicity? Investigating the interaction between nano-objects and bacteria

Clift, Martin J. D. ; Raemy, David O. ; Endes, Carola ; Ali, Zulqurnain ; Lehmann, Andrea D. ; Brandenberger, Christina ; Petri-Fink, Alke ; Wick, Peter ; Parak, Wolfgang J. ; Gehr, Peter ; Schins, Roel P. F. ; Rothen-Rutishauser, Barbara

In: Nanotoxicology, 2013, vol. 7, no. 8, p. 1373–1385

The aim of this study was to assess the interaction of a series of well characterised nano-objects with the Gram negative bacterium Salmonella typhimurium, and how such an interaction may relate to the potential mutagenicity of nano-objects. Transmission electron microscopy showed that nano-objects (Au-PMA-ATTO NPs, CeO₂ NPs, SWCNTs and MWCNTs), as well as CAFs entered S....

Université de Fribourg

Exposure of silver-nanoparticles and silver-ions to lung cells in vitro at the air-liquid interface

Herzog, Fabian ; Clift, Martin JD ; Piccapietra, Flavio ; Behra, Renata ; Schmid, Otmar ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Particle and Fibre Toxicology, 2013, vol. 10, no. 1, p. 11

Background Due to its antibacterial properties, silver (Ag) has been used in more consumer products than any other nanomaterial so far. Despite the promising advantages posed by using Ag-nanoparticles (NPs), their interaction with mammalian systems is currently not fully understood. An exposure route via inhalation is of primary concern for humans in an occupational setting. Aim of this study was...