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Université de Fribourg

Early reperfusion hemodynamics predict recovery in rat hearts: a potential approach towards evaluating cardiac grafts from non-heart-beating donors

Dornbierer, Monika ; Stadelmann, Mathieu ; Sourdon, Joevin ; Gahl, Brigitta ; Cook, Stéphane ; Carrel, Thierry P. ; Tevaearai, Hendrik T. ; Longnus, Sarah L.

In: PLoS ONE, 2012, vol. 7, no. 8, p. e43642

Aims: Cardiac grafts from non-heartbeating donors (NHBDs) could significantly increase organ availability and reduce waiting-list mortality. Reluctance to exploit hearts from NHBDs arises from obligatory delays in procurement leading to periods of warm ischemia and possible subsequent contractile dysfunction. Means for early prediction of graft suitability prior to transplantation are thus...

Université de Fribourg

Changes in wood anatomy in tree rings of Pinus pinaster Ait. following wounding by flash floods

Ballesteros, J.A. ; Stoffel, Markus ; Bodoque, J.M. ; Bollschweiler, Michelle ; Hitz, Oliver ; Díez-Herrero, A.

In: Tree-Ring Research, 2010, vol. 66, no. 2, p. 93-103

This paper analyzes the anatomical response of Pinus pinaster Ait. following wounding by flash floods. A total of 14 wood samples were taken from 14 different scarred trees located on the river banks of the Arroyo Cabrera torrent (Spanish Central System). In addition, 20 increment cores were collected from undisturbed and healthy P. pinaster trees to build a local reference chronology. For the...

Université de Fribourg

Three-dimensional analysis of the anatomical growth response of European conifers to mechanical disturbance

Schneuwly, Dominique M. ; Stoffel, Markus ; Dorren, Luuk K.A. ; Berger, Frédéric

In: Tree Physiology, 2009///doi: 10.1093/treephys/tpp056

Studies on tree reaction after wounding were so far based on artificial wounding or chemical treatment. For the first time, type, spread and intensity of anatomical responses were analyzed and quantified in naturally disturbed Larix decidua Mill., Picea abies (L.) Karst. and Abies alba Mill. trees. The consequences of rockfall impacts on increment growth were assessed at the height of the wounds,...

Université de Fribourg

Formation and spread of callus tissue and tangential rows of resin ducts in Larix decidua and Picea abies following rockfall impacts

Schneuwly, Dominique M. ; Stoffel, Markus ; Bollschweiler, Michelle

In: Tree Physiology, 2009, vol. 29, no. 2, p. 281-289

After mechanical wounding, callus tissue and tangential rows of traumatic resin ducts (TRDs) are formed in many conifer species. This reaction can be used to date past events of geomorphic processes such as rockfall, debris flow and snow avalanches. However, only few points are known about the tangential spread or the timing of callus tissue and TRD formation after wounding. We analyzed 19 Larix...

Université de Fribourg

Sirolimus increases tissue factor expression but not activity in cultured human vascular smooth muscle cells

Zhu, Shengsi ; Viswambharan, Hema ; Gajanayake, Thusitha ; Ming, Xiu-Fen ; Yang, Zhihong

In: BMC Cardiovascular Disorders, 2007, vol. 5, p. 22

Background Sirolimus-eluting stents (CYPHER stents) demonstrated remarkable efficacy in reducing restenosis rates in patients with coronary artery disease. There is a concern of sub-acute and late stent thrombosis. Tissue factor (TF) is critical in thrombosis. This study investigated the effect of sirolimus on TF expression and activity in cultured human vascular smooth muscle cells...

Université de Fribourg

Different vascular smooth muscle cell apoptosis in the human internal mammary artery and the saphenous vein: implications for bypass graft disease

Frischknecht, Karin ; Greutert, Helen ; Weisshaupt, Christian ; Kaspar, Mathias ; Yang, Zhihong ; Lüscher, Thomas F. ; Carrel, Thierry P. ; Tanner, Felix C.

In: Journal of Vascular Research, 2006, vol. 43, no. 4, p. 338-346

The remarkable patency of internal mammary artery (MA) grafts compared to saphenous vein (SV) grafts has been related to different biological properties of the two blood vessels. We examined whether proliferation and apoptosis of vascular smooth muscle cells (VSMC) from human coronary artery bypass vessels differ according to patency rates. Methods and Results: Proliferation rates to serum...

Université de Fribourg

Statins prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway

Kozaia, Toshiyuki ; Eto, Masato ; Yang, Zhihong ; Shimokawa, Hiroaki ; Lüscher, Thomas F.

In: Cardiovascular Research, 2005, vol. 68, p. 475 – 482

Objective: Pulsatile forces regulate vascular remodeling and trigger vascular diseases such as saphenous vein graft disease. The saphenous vein is exposed to high pressure and pulsatility only after implantation. Statins have been proved to reduce the incidence of vein graft failure. Thus, we investigated the molecular mechanisms of pulsatile stretch-induced saphenous vein smooth muscle...

Université de Fribourg

Nitric oxide synthase gene transfer inhibits biological features of bypass graft disease in the human saphenous vein

Tanner, Felix C. ; Largiadèr, Thomas ; Greutert, Helen ; Yang, Zhihong ; Lüscher, Thomas F.

In: Journal of Thoracic and Cardiovascular Surgery, 2004, vol. 127(1), p. 20

Background Bypass graft disease is related to proliferation and migration of vascular smooth muscle cells and to platelet activation with thrombus formation. Nitric oxide inhibits these biological responses; it has never been demonstrated, however, whether this occurs in intact human vascular tissue after endothelial nitric oxide synthase gene transfer. Methods We examined whether endothelial...