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Université de Fribourg

Cost-effectiveness of drug-eluting stents in elderly patients with coronary artery disease: the SENIOR trial

Bulsei, Julie ; Butel, Thibault ; Varenne, Olivier ; Cook, Stéphane ; Cuisset, Thomas ; Carrié, Didier ; Hovasse, Thomas ; Morice, Marie-Claude ; Sinnaeve, Peter R. ; Durand-Zaleski, Isabelle

In: Value in Health, 2019, vol. 22, no. 12, p. 1355–1361

Elderly patients receive bare metal stents instead of drug-eluting stents (DES) to shorten the duration of dual antiplatelet therapy (DAPT). The SENIOR trial compared outcomes between these 2 types of stents combined with a short duration of DAPT. A significant decrease in the number of patients with at least 1 major adverse cardiac and cerebrovascular event (MACCE) was noted in the DES...

Université de Fribourg

Accounting for effective interactions among charged microgels

Aguirre-Manzo, L. A. ; Ledesma-Motolinía, Mónica ; Rojas-Ochoa, Luis Fernando ; Trappe, Véronique ; Callejas-Fernández, J. ; Haro-Pérez, Catalina ; González-Mozuelos, P.

In: Physical Review E, 2019, vol. 100, no. 3, p. 032602

We introduce a theoretical approach to describe structural correlations among charged permeable spheres at finite particle concentrations. This theory explicitly accounts for correlations among microions and between microions and macroions and allows for the proposal of an effective interaction among macroions that successfully captures structural correlations observed in poly- N -isopropyl...

Université de Fribourg

Medicine in the fourth dimension

R.Cederroth, Christopher ; Albrecht, Urs ; Bass, Joseph ; Brown, Steven A. ; Dyhrfjeld-Johnsen, Jonas ; Gachon, Frederic ; Green, Carla B. ; Hastings, Michael H. ; Helfrich-Förster, Charlotte ; B.Hogenesch, John ; Lévi, Francis ; Loudon, Andrew ; B.Lundkvist, Gabriella ; H.Meijer, Johanna ; Rosbash, Michael ; S.Takahashi, Joseph ; Young, Michael ; Canlon, Barbara

In: Cell Metabolism, 2019, vol. 30, no. 2, p. 238–250

The importance of circadian biology has rarely been considered in pre-clinical studies, and even more when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective at nighttime than daytime, whereas for others it is the opposite. This...

Université de Fribourg

Continuous magnetic phase transition in artificial square ice

Sendetskyi, Oles ; Scagnoli, Valerio ; Leo, Naëmi ; Anghinolfi, Luca ; Alberca, Aurora ; Lüning, Jan ; Staub, Urs ; Derlet, Peter Michael ; Heyderman, Laura Jane

In: Physical Review B, 2019, vol. 99, no. 21, p. 214430

Critical behavior is very common in many fields of science and a wide variety of many- body systems exhibit emergent critical phenomena. The beauty of critical phase transitions lies in their scale-free properties, such that the temperature dependence of physical parameters of systems differing at the microscopic scale can be described by the same generic power laws. In this work we establish...

Université de Fribourg

Magnetic-field uniformity in neutron electric-dipole-moment experiments

Abel, C. ; Ayres, N. J. ; Baker, T. ; Ban, G. ; Bison, G. ; Bodek, K. ; Bondar, V. ; Crawford, C. B. ; Chiu, P.-J. ; Chanel, E. ; Chowdhuri, Z. ; Daum, M. ; Dechenaux, B. ; Emmenegger, S. ; Ferraris-Bouchez, L. ; Flaux, P. ; Geltenbort, P. ; Green, K. ; Griffith, W. C. ; Grinten, M. van der ; Harris, P. G. ; Henneck, R. ; Hild, N. ; Iaydjiev, P. ; Ivanov, S. N. ; Kasprzak, M. ; Kermaidic, Y. ; Kirch, K. ; Koch, H.-C. ; Komposch, S. ; Koss, P. A. ; Kozela, A. ; Krempel, J. ; Lauss, B. ; Lefort, T. ; Lemiere, Y. ; Leredde, A. ; Mohanmurthy, P. ; Pais, D. ; Piegsa, F. M. ; Pignol, G. ; Quéméner, G. ; Rawlik, M. ; Rebreyend, D. ; Ries, D. ; Roccia, S. ; Rozpedzik, D. ; Schmidt-Wellenburg, P. ; Schnabel, A. ; Severijns, N. ; Virot, R. ; Weis, Antoine ; Wursten, E. ; Wyszynski, G. ; Zejma, J. ; Zsigmond, G.

In: Physical Review A, 2019, vol. 99, no. 4, p. 042112

Magnetic-field uniformity is of the utmost importance in experiments to measure the electric dipole moment of the neutron. A general parametrization of the magnetic field in terms of harmonic polynomial modes is proposed, going beyond the linear- gradients approximation. We review the main undesirable effects of nonuniformities: depolarization of ultracold neutrons and Larmor frequency shifts...

Consortium of Swiss Academic Libraries

Toward a Cultural-Historical Perspective on the Selection Task

Boissonnade, Romain ; Tartas, Valérie ; Guidetti, Michèle

In: Integrative Psychological and Behavioral Science, 2014, vol. 48, no. 3, p. 341-364

Università della Svizzera italiana

A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation

De Muyt, Arnaud ; Pyatnitskaya, Alexandra ; Andréani, Jessica ; Ranjha, Lepakshi ; Laureau, Raphaëlle ; Fernandez-Vega, Ambra ; Holoch, Daniel ; Girard, Elodie ; Govin, Jérome ; Margueron, Raphaël ; Couté, Yohann ; Cejka, Petr ; Guérois, Raphaël ; Borde, Valérie

In: Genes and development, 2018, vol. 32, no. 3-4, p. 283-296

Meiotic crossover formation requires the stabilization of early recombination intermediates by a set of proteins and occurs within the environment of the chromosome axis, a structure important for the regulation of meiotic recombination events. The molecular mechanisms underlying and connecting crossover recombination and axis localization are elusive. Here, we identified the ZZS...

Université de Fribourg

Mimicking the chemistry of natural eumelanin synthesis: the ke sequence in polypeptides and in proteins allows for a specific control of nanosized functional polydopamine formation

Bergtold, Camille ; Hauser, Daniel ; Alain Chaumont ; El Yakhlifi, Salima ; Mateescu, Mihaela ; Meyer, Florent ; Metz-Boutigue, Marie-Hélène ; Benoît Frisch ; Schaaf, Pierre ; Ihiawakrim, Dris ; Ersen, Ovidiu ; Monnier, Christophe A. ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Ball, Vincent

In: Biomacromolecules, 2018, vol. 19, no. 9, p. 3693–3704

The oxidation of dopamine and of other catecholamines leads to the formation of conformal films on the surface of all known materials and to the formation of a precipitate in solution. In some cases, it has been shown that the addition of additives in the dopamine solution, like certain surfactants or polymers, polyelectrolytes, and certain proteins, allows to get polydopamine nanoparticles...

Université de Fribourg

Circularly polarized reflection from the scarab beetle Chalcothea smaragdina: light scattering by a dual photonic structure

McDonald, Luke T. ; Finlayson, Ewan D. ; Wilts, Bodo D. ; Vukusic, Pete

In: Interface Focus, 2017, vol. 7, no. 4, p. 20160129

Helicoidal architectures comprising various polysaccharides, such as chitin and cellulose, have been reported in biological systems. In some cases, these architectures exhibit stunning optical properties analogous to ordered cholesteric liquid crystal phases. In this work, we characterize the circularly polarized reflectance and optical scattering from the cuticle of the beetle Chalcothea...