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Université de Fribourg

Dimercaptosuccinic acid in combination with carbapenems against isogenic strains of Escherichia coli producing or not producing a metallo-β-lactamase in vitro and in murine peritonitis

Cheminet, G. ; de Lastours, V. ; Poirel, Laurent ; Chau, F. ; Peoc’h, K. ; Massias, L. ; Fantin, B. ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2020, vol. 75, no. 12, p. 3593–3600

Background: Carbapenemase-producing Enterobacterales represent a major therapeutic challenge. MBLs, requiring zinc at their catalytic site, could be inhibited by meso-dimercaptosuccinic acid (DMSA), a heavy metal chelator already widely used for treating lead intoxication.Objectives: To evaluate the activity of carbapenems alone or combined with DMSA against MBL-producing Escherichia coli in...

Haute école de gestion de Genève

Do socially responsible investments outperform conventional ones ?

Schaub, Laurent-Xavier ; Ruiz, Frédéric (Dir.)

Mémoire de bachelor : Haute école de gestion de Genève, 2020 ; TDIBM 87.

The literature has seen a growing number of studies addressing the topic of sustainable finance, while firms also seem to be keener on undertaking and advertising societal actions. The role firms play in society has been evolving, especially due to the rising demand for corporate social responsibilities. The question that recurrently arises is whether being socially responsible will allow...

Haute école de gestion de Genève

The influence of Green Nudges in a marketing strategy to reduce consumption of natural resources for packaging while maintaining or increasing profits

Mueller, Nadja Jennifer ; Shepherd, Mark (Dir.)

Mémoire de bachelor : Haute école de gestion de Genève, 2020 ; TDIBM 95.

Environmental pollution became a serious problem and is impacting our planet today. According to the World Economic Forum, plastic “is one of the world’s leading drivers of climate change”. Literature states that cardboard boxes, such as Tetra Pak, require less natural resources than plastic bottles. Making a change and decreasing environmental pollution requires the active involvement...

Public access from 04.03.2021
Università della Svizzera italiana

A hierarchy of graph-based methods to study the behavior of immune cells in vivo

Pizzagalli, Diego Ulisse ; Krause, Rolf (Dir.) ; Gonzalez, Santiago Fernandez (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020INFO018.

The immune system has a critical role in diseases of primary importance such as infections and cancer. Hence, it represents a target for novel therapeutic strategies. However, the immune system relies on a complex network of cell-to-cell interactions which remains largely unknown, or difficult to be interpreted. The combination of experimental data with computational methods is of paramount...

Université de Fribourg

Traditional Amazonian Medicine Adapted To Treat Substance Use Disorder

Berlowitz, Ilana ; Martin Soelch, Chantal (Dir.)

Thèse de doctorat : Université de Fribourg, 2017.

Schädlicher Substanzgebrauch gilt als eines der wesentlichsten Gesundheitsprobleme weltweit, welches auf individueller sowie gesellschaftlicher Ebene mit erheblichen Kosten und Leidensdruck verbunden ist. Substanzgebrauchsstörungen gelten heute als chronische Erkrankung, für deren Versorgung noch nach langfristig wirksamen Lösungen gesucht wird. Heutzutage wird für die Behandlung...

Public access from 04.12.2022
Università della Svizzera italiana

Analyzing cultural localization in online tourism promotion

Mele, Emanuele ; Cantoni, Lorenzo (Dir.) ; Kerkhof, Peter (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020COM006.

Tourism and culture are strongly intertwined. People can experience culture before, during and after their journey, both in the offline and in the online world. Arguably, the internet is among the main sources of inspiration and information retrieval for tourists, who navigate social media and websites to know more about the destination, its products and services. Following the developments in...

Université de Fribourg

Never and under cervical cancer screening in Switzerland and Belgium: trends and inequalities

Jolidon, Vladimir ; Prez, Vincent De ; Willems, Barbara ; Bracke, Piet ; Cullati, Stéphane ; Burton-Jeangros, Claudine

In: BMC Public Health, 2020, vol. 20, no. 1, p. 1517

Research on inequalities in cervical cancer screening (CCS) participation has overlooked the distinction between ‘never-’ and ‘under-screeners’ while different socioeconomic and demographic determinants may underlie ‘non-’ and ‘under-’ screening participation. This study examines socioeconomic and demographic inequalities in never and under CCS participation. We compare...

Public access from 21.09.2022
Università della Svizzera italiana

Corporate social responsibility and information and communication technology in the digital age

Schultz, Mario Dominik ; Seele, Peter (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020COM003.

Pervasive digital technologies are transforming economies and societies worldwide. This dissertation focuses on Corporate Social Responsibilities (CSR) as the dominant model of business ethics over the last decades, in an attempt to better understand the digital transformation. Digitalization represents a fundamental and challenging transformation and promises to touch on almost all areas of...

Université de Neuchâtel

Individuals’ strategies for wellbeing during the integration process : an empirical study of capabilities and opportunities through the eyes of Syrian refugees in the Canton of Vaud, in Switzerland

Widmer, Irina Alexandra ; Suter, Brigitte (Dir.)

Mémoire de master : Université de Neuchâtel, 2020.

Integration concerns everyone in society as a constantly on-going process of constructing belonging and participation as a member of the group. The common objective of the process for individuals is to increase their subjective wellbeing, according to their individual values. However, refugees undergo an extreme case of integration, with all aspects of their life being impacted at once....

Université de Fribourg

Mitophagy and mitochondria biogenesis are differentially induced in rat skeletal muscles during immobilization and/or remobilization

Deval, Christiane ; Calonne, Julie ; Coudy-Gandilhon, Cécile ; Vazeille, Emilie ; Bechet, Daniel ; Polge, Cécile ; Taillandier, Daniel ; Attaix, Didier ; Combaret, Lydie

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 10, p. 3691

Mitochondria alterations are a classical feature of muscle immobilization, and autophagy is required for the elimination of deficient mitochondria (mitophagy) and the maintenance of muscle mass. We focused on the regulation of mitochondrial quality control during immobilization and remobilization in rat gastrocnemius (GA) and tibialis anterior (TA) muscles, which have very different atrophy...