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Université de Fribourg

Slow-targeted release of a ruthenium anticancer agent from vitamin B 12 functionalized marine diatom microalgae

Delasoie, Joachim ; Rossier, Jérémie ; Haeni, Laetitia ; Rothen-Rutishauser, Barbara ; Zobi, Fabio

In: Dalton Transactions, 2018, vol. 47, no. 48, p. 17221–17232

Herein we report the synthesis of a new biomaterial designed for targeted delivery of poorly water-soluble inorganic anticancer drugs, with a focus on colorectal cancer. Diatomaceous earth microparticles derived from marine microalgae were coated with vitamin B12 (cyanocobalamin) as a tumor targeting agent and loaded with the well- known anticancer agents cisplatin, 5-fluorouracil (5-FU), and...

Université de Fribourg

Cytotoxicity of Mn-based photoCORMs of ethynyl-α-diimine ligands against different cancer cell lines: The key role of CO-depleted metal fragments

Rossier, Jeremie ; Delasoie, Joachim ; Haeni, Laetitia ; Hauser, Daniel ; Rothen-Rutishauser, Barbara ; Zobi, Fabio

In: Journal of Inorganic Biochemistry, 2020, vol. 209, p. 111122

A series of tricarbonyl manganese complexes bearing 4-ethynyl-2,2′-bipyridine and 5- ethynyl-1,10-phenanthroline α-diimine ligands were synthetized, characterized and conjugated to vitamin B12, previously used as a vector for drug delivery, to take advantage of its water solubility and specificity toward cancer cells. The compounds act as photoactivatable carbon monoxide-releasing molecules...

Université de Fribourg

Tautomerism and self-association in the solution of new pinene-bipyridine and pinene-phenanthroline derivatives

Solea, Atena B. ; Cornu, Ivan ; Deneva, Vera ; Crochet, Aurélien ; Fromm, Katharina M. ; Antonov, Liudmil ; Allemann, Christophe ; Mamula, Olimpia

In: Molecules, 2020, vol. 25, no. 2, p. 298

Two novel pinene-type ligands have been synthesized and their tautomeric and self- associating behavior studied in solution and in the solid state. The first ligand, an acetylated derivative of 5,6-pinene-bipyridine, displays keto-enol tautomerism in solution. This tautomeric equilibrium was studied by NMR and UV-Vis spectroscopy in various solvents, and the results were compared with the ones...

Université de Fribourg

Correlation of MLCTs of Group 7 fac-[M(CO)3]+ complexes (M = Mn, Re) with bipyridine, pyridinylpyrazine, azopyridine, and pyridin-2-ylmethanimine type ligands for rational photoCORM design

Kottelat, Emmanuel ; Lucarini, Fiorella ; Crochet, Aurélien ; Ruggi, Albert ; Zobi, Fabio

In: European Journal of Inorganic Chemistry, 2019, vol. 2019, no. 33, p. 3758–3768

A mathematical correlation of the MLCT absorption maxima of structurally related fac‐ [M(CO)3L2Br] complexes (M = Mn, Re; L2 = bidentate ligand) is obtained by the comparison of a total of 50 species bearing bipyridine, pyridinylpyrazine, azopyridine and pyridin‐2‐ylmethanimine L2 type ligands. The empirical relationship is first derived by the initial comparison of the MLCT absorption...

Université de Fribourg

Novel iron tweezers complexes for hydrogenation and polymerization of olefins

Mafua, Roger ; Jenny, Titus A. (Dir.)

Thèse de doctorat : Université de Fribourg, 2006 ; no. 1503.

The use of organometallic complexes as catalysts became a very significant topic in the field of material chemistry. However, despite of this development, only few of them contain iron(II), except the tridentate complex diimine pyridine developed by Gibson and Brookhart and employed in the olefin polymerization. Unfortunately, this model suffers by its lack of tolerance towards the minor changes...