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Université de Fribourg

Rapid evolution of invasive traits facilitates the invasion of common ragweed, Ambrosia artemisiifolia

Sun, Yan ; Roderick, George K.

In: Journal of Ecology, 2019, vol. 107, no. 6, p. 2673–2687

Invasive alien plants, together with organisms introduced for biological control, are ideal study systems with which to address questions of whether, and how fast, organisms adapt to changing environments. We compared populations of common ragweed, Ambrosia artemisiifolia, from native (USA) and introduced (China) ranges at similar latitudes, together with herbivores introduced for biological...

Université de Fribourg

Structural insights into the EGO-TC–mediated membrane tethering of the TORC1-regulatory Rag GTPases

Zhang, Tianlong ; Péli-Gulli, Marie-Pierre ; Zhang, Zhen ; Tang, Xin ; Ye, Jie ; Virgilio, Claudio De ; Ding, Jianping

In: Science Advances, 2019, vol. 5, no. 9, p. eaax8164

The Rag/Gtr GTPases serve as a central module in the nutrient-sensing signaling network upstream of TORC1. In yeast, the anchoring of Gtr1-Gtr2 to membranes depends on the Ego1-Ego2-Ego3 ternary complex (EGO-TC), resulting in an EGO- TC-Gtr1-Gtr2 complex (EGOC). EGO-TC and human Ragulator share no obvious sequence similarities and also differ in their composition with respect to the number of ...

Università della Svizzera italiana

Optimization of anchor nodes placement in wireless localization networks

Balac, Katarina ; Malek, Miroslaw (Dir.) ; Prevostini, Mauro (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO009.

This work focuses on optimizing node placement for time-of-flight-based wireless localization networks. Main motivation are critical safety applications. The first part of my thesis is an experimental study on in-tunnel vehicle localization. In- tunnel localization of vehicles is crucial for emergency management, especially for large trucks transporting dangerous goods such as inflammable...

Université de Fribourg

How network topologies impact project alliance performance: evidence from the movie industry

Zhang, Xin-Jie ; Tang, Yong ; Xiong, Jason ; Wang, Wei-Jia ; Zhang, Yi-Cheng

In: Entropy, 2019, vol. 21, no. 9, p. 859

In many industries, partners are interconnected in project alliances that have limited lifespans and clearly-defined boundaries. The transparency of the movie industry provides a unique opportunity to study how alliance network topologies impact the performance of project alliances from the perspectives of social networks and organization theories. In this work, we compiled a massive movie...

Université de Fribourg

Multilevel regulation of the glass locus during Drosophila eye development

Fritsch, Cornelia ; Bernardo-Garcia, F. Javier ; Humberg, Tim-Henning ; Mishra, Abhishek Kumar ; Miellet, Sara ; Almeida, Silvia ; Frochaux, Michael V. ; Deplancke, Bart ; Huber, Armin ; Sprecher, Simon G.

In: PLOS Genetics, 2019, vol. 15, no. 7, p. e1008269

Development of eye tissue is initiated by a conserved set of transcription factors termed retinal determination network (RDN). In the fruit fly Drosophila melanogaster, the zinc-finger transcription factor Glass acts directly downstream of the RDN to control identity of photoreceptor as well as non-photoreceptor cells. Tight control of spatial and temporal gene expression is a critical...

Université de Fribourg

Multilayered control of protein turnover by torc1 and atg1

Hu, Zehan ; Raucci, Serena ; Jaquenoud, Malika ; Hatakeyama, Riko ; Stumpe, Michael ; Rohr, Rudolf ; Reggiori, Fulvio ; Virgilio, Claudio De ; Dengjel, Jörn

In: Cell Reports, 2019, vol. 28, no. 13, p. 3486-3496.e6

The target of rapamycin complex 1 (TORC1) is a master regulator of cell homeostasis, which promotes anabolic reactions and synchronously inhibits catabolic processes such as autophagy-mediated protein degradation. Its prime autophagy target is Atg13, a subunit of the Atg1 kinase complex that acts as the gatekeeper of canonical autophagy. To study whether the activities of TORC1 and Atg1 are...

Université de Fribourg

Opinion dynamics and wisdom under conformity

Buechel, Berno ; Hellmann, Tim ; Kloessner, Stefan

In: Journal of economic dynamics and control, 2015, vol. 52, p. 240-257

We study a dynamic model of opinion formation in social networks. In our model, boundedly rational agents update opinions by averaging over their neighbors’ expressed opinions, but may misrepresent their own opinion by conforming or counter-conforming with their neighbors. We show that an agent׳s social influence on the long-run group opinion is increasing in network centrality and...

Université de Fribourg

Nodesketch: highly-efficient graph embeddings via recursive sketching

Yang, Dingqi ; Rosso, Paolo ; Li, Bin ; Cudre-Mauroux, Philippe

In: Proceedings of the 25th ACM SIGKDD International Conference on Knowledge Discovery & Data Mining, 2019, p. 1162–1172

Embeddings have become a key paradigm to learn graph representations and facilitate downstream graph analysis tasks. Existing graph embedding techniques either sample a large number of node pairs from a graph to learn node embeddings via stochastic optimization, or factorize a high-order proximity/adjacency matrix of the graph via expensive matrix factorization. However, these techniques...

Université de Fribourg

Revealing ‘plasmaron’ feature in DySb by optical spectroscopy study

Ban, W J ; Wu, D S ; Xu, Bing ; Luo, J L ; Xiao, Hong

In: Journal of Physics: Condensed Matter, 2019, vol. 31, no. 40, p. 405701

We report magnetic susceptibility, resistivity and optical spectroscopy study on single crystal sample DySb. It exhibits extremely large magnetoresistance (XMR), and a magnetic phase transition from paramagnetic (PM) to antiferromagnetic (AFM) state at about 10 K. A 'screened' plasma edge at about 4000 cm−1 is revealed by optical measurement, which suggests that the material has a low...

Université de Fribourg

Executive control training does not generalize, even when associated with plastic changes in domain-general prefrontal areas

Simonet, Marie ; Crettaz von Roten, Fabienne ; Spierer, Lucas ; Barral, Jérôme

In: NeuroImage, 2019, vol. 197, p. 457–469

How executive function training paradigms can be effectively designed to promote a transfer of the effects of interventions to untrained tasks remains unclear. Here, we tested the hypothesis that training with a complex task involving motor, perceptual and task-set control components would result in more transfer than training with a simple motor control task, because the Complex training...