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Université de Fribourg

Excitonic channels from bio-inspired templated supramolecular assembly of J-aggregate nanowires

Anantharaman, Surendra B. ; Messmer, Daniel ; Sadeghpour, Amin ; Salentinig, Stefan ; Nüescha, Frank ; Heier, Jakob

In: Nanoscale, 2019, vol. 11, no. 14, p. 6929–6938

Supramolecular assemblies with controlled morphology are of paramount importance for energy transport in organic semiconductors. Despite considerable freedom in molecular design, the preparation of dyes that form one dimensional J-aggregates is challenging. Here, we demonstrate a simple and effective route to functionalize dendronized polymers (DPs) with J-aggregates to construct tubular...

Université de Fribourg

Synthesis of different glutathione–sulfur mustard adducts of verified and potential biomarkers

Bielmann, Andreas ; Sambiagio, Nicolas ; Wehr, Nathalie ; Gerber-Lemaire, Sandrine ; Bochet, Christian G. ; Curty, Christophe

In: RSC Advances, 2018, vol. 8, no. 42, p. 23881–23890

Sulfur Mustard (SM) is a blistering agent used as a chemical weapon. Glutathione (GSH) is involved in the β-lyase degradation pathway of SM and recently, bioadducts between SM and GSH were observed in vitro. While these bioadducts have never been isolated from in vivo tests or real poisoning with SM, they could be of interest as potential future biomarkers for the retrospective validation of...

Consortium of Swiss Academic Libraries

Expertise in performance assessment: assessors' perspectives

Berendonk, Christoph ; Stalmeijer, Renée ; Schuwirth, Lambert

In: Advances in Health Sciences Education, 2013, vol. 18, no. 4, p. 559-571

Université de Fribourg

Solid‐phase synthesis of the aged‐nonapeptide‐nerve‐agent adduct of butyrylcholinesterase as reference materials for analytical verification

Bielmann, Andreas ; Curty, Christophe ; Bochet, Christian G.

In: Helvetica Chimica Acta, 2017, vol. 100, no. 11, p. -

Two pathways were developed and investigated for the synthesis of the ‘aged’- nonapeptide nerve-agent bioadduct of human butyrylcholinesterase (BuChE). Considering the fast ageing of nerve-agent adducts of BuChE in patients and biomedical samples this target molecule is of paramount relevance for quantitative analysis with respect to the Chemical Weapons Convention. Two approaches using a ...

Université de Fribourg

A mechano- and thermoresponsive luminescent cyclophane

Sagara, Yoshimitsu ; Simon, Yoan C. ; Tamaoki, Nobuyuki ; Weder, Christoph

In: Chemical Communications, 2016, vol. 52, p. 5694–5697

The first fluorescent cyclophane with mechano- and thermoresponsive solid-state fluorescence characteristics is reported. The new cyclophane comprises two 9,10-bis(phenylethynyl)anthracene moieties that are bridged by tetraethylene glycol spacers. The stimuli-responsiveness is based on molecular assembly changes.