In: L'endocrinologo, 2021, vol. 22, no. 3, p. 225–230
L’esame strumentale più comunemente utilizzato per valutare il rischio di malignità del nodulo tiroideo è l’ecografia. Con questo esame è possibile individuare posizione, dimensioni e caratteristiche del nodulo. Dal momento che l’uso dei singoli aspetti ecografici di sospetto ha dimostrato una bassa riproducibilità nell’indicazione all’agoaspirato, nel corso degli ultimi anni...
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In: Journal of Hip Preservation Surgery, 2017, vol. 4, no. 4, p. 269-275
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In: Blood, 2020, vol. 135, no. 15, p. 1244–1254
CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The cutoff value for the extensively validated 30% of positive CLL cells is able to separate CLL patients into 2 subgroups with different prognoses, but it does not consider the pattern of CD49d expression. In the present study, we analyzed a cohort of 1630 CLL samples and identified the presence of ∼20% of CLL...
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In: Haematologica, 2020, vol. 105, no. 2, p. 448-456
BIRC3 is a recurrently mutated gene in chronic lymphocytic leukemia (CLL) but the functional implications of BIRC3 mutations are largely unexplored. Furthermore, little is known about the prognostic impact of BIRC3 mutations in CLL cohorts homogeneously treated with first-line fludarabine, cyclophosphamide, and rituximab (FCR). By immunoblotting analysis, we showed that the non-canonical...
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In: Frontiers in Immunology, 2020, vol. 11, p. -
The chemokine receptor CXCR4 plays a fundamental role in homeostasis and pathology by orchestrating recruitment and positioning of immune cells, under the guidance of a CXCL12 gradient. The ability of chemokines to form heterocomplexes, enhancing their function, represents an additional level of regulation on their cognate receptors. In particular, the multi-faceted activity of the...
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In: Frontiers in immunology, 2017, vol. 8, p. 1563
Vaccinology aims to understand what factors drive vaccine-induced immunity and protection. For many vaccines, however, the mechanisms underlying immunity and protection remain incompletely characterized at best, and except for neutralizing antibodies induced by viral vaccines, few correlates of protection exist. Recent omics and systems biology big data platforms have yielded valuable...
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In: Frontiers in immunology, 2017, vol. 8, p. 415
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In: Frontiers in immunology, 2019, vol. 10, p. 1391
Pemphigus vulgaris (PV) is an autoimmune bullous disease of the skin and mucous membranes characterized by the presence of circulating and tissue-bound autoantibodies against keratinocyte cell surface antigens, specifically desmoglein (Dsg) 1 and 3. The pathogenic role of anti-Dsg antibodies is well-established, while the mechanism of blister formation is only partly defined. We have applied...
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In: Plos one, 2014, vol. 9, no. 10, p. e111285
Immunosuppressive regulatory T cells (Tregs) have been hypothesized to exert a protective role in animal models of spontaneous (Buffalo/Mna) and/or drug induced (Adriamycin) nephrotic syndrome. In this study, we thought to define whether Tregs can modify the outcome of LPS nephropathy utilizing IL-2 as inducer of tissue and circulating Tregs. LPS (12 mg/Kg) was given as single shot in C57BL/6,...
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In: Frontiers in immunology, 2014, vol. 5, p. 259
Thymocytes and thymic epithelial cells (TECs) cross-talk is essential to support T cell development and preserve thymic architecture and maturation of TECs and Foxp3+ natural regulatory T cells. Accordingly, disruption of thymic lymphostromal cross-talk may have major implications on the thymic mechanisms that govern T cell tolerance. Several genetic defects have been described in humans that...
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