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Università della Svizzera italiana

Glomerular macrophages in human auto- and allo-immune nephritis

Moll, Solange ; Angeletti, Andrea ; Scapozza, Leonardo ; Cavalli, Andrea ; Ghiggeri, Gian Marco ; Prunotto, Marco

In: Cells, 2021, vol. 10, no. 3, p. 19 p

Macrophages are involved in tissue homeostasis. They participate in inflammatory episodes and are involved in tissue repair. Macrophages are characterized by a phenotypic heterogeneity and a profound cell plasticity. In the kidney, and more particularly within glomeruli, macrophages are thought to play a maintenance role that is potentially critical for preserving a normal glomerular structure....

Università della Svizzera italiana

LPS nephropathy in mice is ameliorated by IL-2 independently of regulatory T cells activity

Bertelli, Roberta ; Di Donato, Armando ; Cioni, Michela ; Grassi, Fabio ; Ikehata, Masami ; Bonanni, Alice ; Rastaldi, Maria Pia ; Ghiggeri, Gian Marco

In: Plos one, 2014, vol. 9, no. 10, p. e111285

Immunosuppressive regulatory T cells (Tregs) have been hypothesized to exert a protective role in animal models of spontaneous (Buffalo/Mna) and/or drug induced (Adriamycin) nephrotic syndrome. In this study, we thought to define whether Tregs can modify the outcome of LPS nephropathy utilizing IL-2 as inducer of tissue and circulating Tregs. LPS (12 mg/Kg) was given as single shot in C57BL/6,...

Consortium of Swiss Academic Libraries

Immunological aspects of atherosclerosis

Garrido-Urbani, S. ; Meguenani, M. ; Montecucco, F. ; Imhof, B.

In: Seminars in Immunopathology, 2014, vol. 36, no. 1, p. 73-91

Consortium of Swiss Academic Libraries

Atherosclerosis is an inflammatory disease

Montecucco, Fabrizio ; Mach, François

In: Seminars in Immunopathology, 2009, vol. 31, no. 1, p. 1-3

Consortium of Swiss Academic Libraries

Tumour-targeting properties of antibodies specific to MMP-1A, MMP-2 and MMP-3

Pfaffen, Stefanie ; Frey, Katharina ; Stutz, Irène ; Roesli, Christoph ; Neri, Dario

In: European Journal of Nuclear Medicine and Molecular Imaging, 2010, vol. 37, no. 8, p. 1559-1565

Consortium of Swiss Academic Libraries

Anti-retinal autoantibodies in experimental ocular and systemic toxoplasmosis

Garweg, Justus ; de Kozak, Yvonne ; Goldenberg, Brigitte ; Boehnke, Matthias

In: Graefe's Archive for Clinical and Experimental Ophthalmology, 2010, vol. 248, no. 4, p. 573-584