Università della Svizzera italiana

PPARgamma in dendritic cells and T cells drives pathogenic type-2 effector responses in lung inflammation

Nobs, Samuel Philip ; Natali, Sara ; Pohlmeier, Lea ; Okreglicka, Katarzyna ; Schneider, Christoph ; Kurrer, Michael ; Sallusto, Federica ; Kopf, Manfred

In: Journal of experimental medicine, 2017, vol. 214, no. 10, p. 3015-3035

Type-2 immune responses are well-established drivers of chronic inflammatory diseases, such as asthma, and represent a large burden on public health systems. The transcription factor PPARγ is known to promote M2-macrophage and alveolar macrophage development. Here, we report that PPARγ plays a key role in both T cells and dendritic cells (DCs) for development of type-2 immune responses. It...