Université de Fribourg

Comparison of cannabinoid concentrations in oral fluid and whole blood between occasional and regular cannabis smokers prior to and after smoking a cannabis joint

Fabritius, Marie ; Chtioui, Haithem ; Battistella, Giovanni ; Annoni, Jean Marie ; Dao, Kim ; Favrat, Bernard ; Fornari, Eleonora ; Lauer, Estelle ; Maeder, Philippe ; Giroud, Christian

In: Analytical and Bioanalytical Chemistry, 2013, vol. 405, no. 30, p. 9791–9803

A cross-over controlled administration study of smoked cannabis was carried out on occasional and heavy smokers. The participants smoked a joint (11 % Δ9-tetrahydrocannabinol (THC)) or a matching placebo on two different occasions. Whole blood (WB) and oral fluid (OF) samples were collected before and up to 3.5 h after smoking the joints. Pharmacokinetic analyses were obtained from these data....

Université de Fribourg

THCCOOH concentrations in whole blood: Are they useful in discriminating occasional from heavy smokers?

Fabritius, Marie ; Favrat, Bernard ; Chtioui, Haithem ; Battistella, Giovanni ; Annoni, Jean-Marie ; Appenzeller, Monique ; Dao, Kim ; Fornari, Eleonora ; Lauer, Estelle ; Mall, Jean-Frédéric ; Maeder, Philippe ; Mangin, Patrice ; Staub, Christian ; Giroud, Christian

In: Drug Testing and Analysis, 2013, vol. 6, no. 1-2, p. 155–163

Some forensic and clinical circumstances require knowledge of the frequency of drug use. Care of the patient, administrative, and legal consequences will be different if the subject is a regular or an occasional cannabis smoker. To this end, 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH) has been proposed as a criterion to help to distinguish between these two groups of users. However, to...