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Université de Fribourg

Quantification of multiple bile acids in uninephrectomized rats using ultra-performance liquid chromatography-tandem mass spectrometry

Penno, Carlos A. ; Arsenijevic, Denis ; Cunha, Thierry Da ; Kullak-Ublic, Gerd A. ; Montani, Jean-Pierre ; Odermatt, Alex

In: Analytical Methods, 2013, vol. 5, p. 1155-1164

In order to study the roles of individual BAs and due to limited blood sample volumes available from experimental animals, improved methods for the simultaneous quantification of multiple BAs are needed. We developed and validated an ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the quantification of 24 BAs, including 11 unconjugated, 6...

Université de Fribourg

A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth : a randle cycle favoring fat storage

Marcelino, Helena ; Veyrat-Durebex, Christelle ; Summermatter, Serge ; Sarafian, Delphine ; Miles-Chan, Jennifer L. ; Arsenijevic, Denis ; Zani, Fabio ; Montani, Jean-Pierre ; Seydoux, Josiane ; Solinas, Giovanni ; Rohner-Jeanrenaud, Françoise ; Dulloo, Abdul G.

In: Diabetes, 2013, vol. 62, no. 2, p. 362-372

Catch-up growth, a risk factor for type 2 diabetes, is characterized by hyperinsulinemia and accelerated body fat recovery. Using a rat model of semistarvation-refeeding that exhibits catch-up fat, we previously reported that during refeeding on a low-fat diet, glucose tolerance is normal but insulin-dependent glucose utilization is decreased in skeletal muscle and increased in adipose...

Université de Fribourg

Adaptive thermogenesis in human body weight regulation: more of a concept than a measurable entity?

Dulloo, Abdul G. ; Jacquet, Jean ; Montani, Jean-Pierre ; Schutz, Yves

In: Obesity Reviews, 2012, vol. 13, no. S2, p. 105–121

According to Lavoisier, ‘Life is combustion’. But to what extent humans adapt to changes in food intake through adaptive thermogenesis – by turning down the rate of heat production during energy deficit (so as to conserve energy) or turning it up during overnutrition (so as to dissipate excess calories) – has been one of the most controversial issues in nutritional sciences over the past...

Université de Fribourg

Body composition, inflammation and thermogenesis in pathways to obesity and the metabolic syndrome: an overview

Dulloo, Abdul G. ; Montani, Jean-Pierre

In: Obesity Reviews, 2012, vol. 13, no. S2, p. 1–5

According to the World Health Organization, overweight and obesity are defined as abnormal or excessive fat accumulation that presents a risk to health. What constitutes ‘abnormal’ fat accumulation in this definition is not specified, but this most likely represents a consensus term that encapsulates the importance of adipose tissue dysfunctions, rather than solely excess fat per se, in the...

Université de Fribourg

Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging

Yepuri, Gautham ; Velagapudi, Srividya ; Xiong, Yuyan ; Rajapakse, Angana G. ; Montani, Jean-Pierre ; Ming, Xiu-Fen ; Yang, Zhihong

In: Aging Cell, 2012, p. -

Augmented activities of both arginase and S6K1 are involved in endothelial dysfunction in aging. This study was to investigate whether or not there is a crosstalk between arginase and S6K1 in endothelial inflammation and aging in senescent human umbilical vein endothelial cells and in aging mouse models. We show increased arginase-II (Arg-II) expression/activity in senescent endothelial cells....

Université de Fribourg

Perspectives of targeting mTORC1–S6K1 in cardiovascular aging

Ming, Xiu-Fen ; Montani, Jean-Pierre ; Yang, Zhihong

In: Frontiers in Vascular Physiology, 2012, vol. 3, p. 5

The global population aging is accelerating and age-associated diseases including cardiovascular diseases become more challenging. The underlying mechanisms of aging and age-associated cardiovascular dysfunction remain elusive. There are substantial evidences demonstrating a pivotal role of the mammalian target of rapamycin complex 1 (mTORC1) and its down-stream effector S6K1 signaling in...

Université de Fribourg

PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance

Becattini, Barbara ; Marone, Romina ; Zani, Fabio ; Arsenijevic, Denis ; Seydoux, Josiane ; Montani, Jean-Pierre ; Dulloo, Abdul G. ; Thorens, Bernard ; Preitner, Frédéric ; Wymann, Matthias P. ; Solinas, Giovanni

In: Proceedings of the National Academy of Sciences of the United States of America, 2011, vol. 108, no. 42, p. E854-E863

Obesity is associated with a chronic low-grade inflammation, and specific antiinflammatory interventions may be beneficial for the treatment of type 2 diabetes and other obesity-related diseases. The lipid kinase PI3Kγ is a central proinflammatory signal transducer that plays a major role in leukocyte chemotaxis, mast cell degranulation, and endothelial cell activation. It was also reported that...

Université de Fribourg

Non-contact assessment of waist circumference: will tape measurements become progressively obsolete?

Schutz, Y. ; Sarafian, D. ; Miles, J. L. ; Montani, Jean-Pierre ; Dulloo, Abdul G.

In: European Journal of Clinical Nutrition, 2011, p. -

Waist circumference (WC) is a key variable to assess in health management as it is a proxy of abdominal fat mass and a surrogate marker of cardiometabolic disease risk, including the metabolic syndrome. Recently, a portable non-contact device calculating WC (ViScan) has been developed, which hence allows the tracking of WC independently of the inter-investigators error. We compared WC values...

Université de Fribourg

Does mental arithmetic before head up tilt have an effect on the orthostatic cardiovascular and hormonal responses?

Goswami, Nandu ; Lackner, Helmut Karl ; Papousek, Ilona ; Montani, Jean-Pierre ; Jezova, Daniela ; Hinghofer-Szalkay, Helmut G.

In: Acta Astronautica, 2011, vol. 68, no. 9-10, p. 1589-1594

Passive head up tilt (HUT) and mental arithmetic (MA) are commonly used for providing mental and orthostatic challenges, respectively. In animal experiments, even a single exposure to a stressor has been shown to modify the response to subsequent stress stimulus. We investigated whether MA applied before HUT elicits synergistic responses in orthostatic heart rate (HR), cardiac output (CO),...