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Université de Fribourg

Cue recognition and integration – eye tracking evidence of processing differences in sentence comprehension in aphasia

Schumacher, Rahel ; Cazzoli, Dario ; Eggenberger, Noëmi ; Preisig, Basil ; Nef, Tobias ; Nyffeler, Thomas ; Gutbrod, Klemens ; Annoni, Jean-Marie ; Müri, René M.

In: PLoS ONE, 2015, vol. 10, no. 11, p. e0142853

We aimed at further elucidating whether aphasic patients’ difficulties in understanding non-canonical sentence structures, such as Passive or Object-Verb-Subject sentences, can be attributed to impaired morphosyntactic cue recognition, and to problems in integrating competing interpretations.Methods: A sentence-picture matching task with canonical and non-canonical spoken sentences was...

Université de Fribourg

Brain activity during observation and motor imagery of different balance tasks: An fMRI study

Taube, Wolfgang ; Mouthon, Michael ; Leukel, Christian ; Hoogewoud, Henri-Marcel ; Annoni, Jean-Marie ; Keller, Martin

In: Cortex, 2015, vol. 64, p. 102–114

After immobilization, patients show impaired postural control and increased risk of falling. Therefore, loss of balance control should already be counteracted during immobilization. Previously, studies have demonstrated that both motor imagery (MI) and action observation (AO) can improve motor performance. The current study elaborated how the brain is activated during imagination and observation...

Université de Fribourg

Perception of co-speech gestures in aphasic patients: A visual exploration study during the observation of dyadic conversations

Preisig, Basil C. ; Eggenberger, Noëmi ; Zito, Giuseppe ; Vanbellingen, Tim ; Schumacher, Rahel ; Hopfner, Simone ; Nyffeler, Thomas ; Gutbrod, Klemens ; Annoni, Jean-Marie ; Bohlhalter, Stephan ; Müri, René M.

In: Cortex, 2015, vol. 64, p. 157–168

Co-speech gestures are part of nonverbal communication during conversations. They either support the verbal message or provide the interlocutor with additional information. Furthermore, they prompt as nonverbal cues the cooperative process of turn taking. In the present study, we investigated the influence of co-speech gestures on the perception of dyadic dialogue in aphasic patients. In...

Université de Fribourg

Impairment of both languages in late bilinguals with dementia of the Alzheimer type

Manchon, Mélanie ; Buetler, Karin ; Colombo, Françoise ; Spierer, Lucas ; Assal, Frédéric ; Annoni, Jean-Marie

In: Bilingualism: Language and Cognition, 2014, vol. 18, no. 01, p. 90–100

Neuropsychological theories raise the question if in late bilinguals with dementia of the Alzheimer type (DAT), the second language (L2) may be more impaired than the first (L1). We compared language performance in different tasks of oral comprehension (semantic and syntactic) and production (naming, repetition and fluency) in L1 and L2 in a group of 13 late proficient bilinguals wit DAT...

Université de Fribourg

Feasibility of a multiple-choice mini mental state examination for chronically critically ill patients

Miguélez, Marta ; Merlani, Paolo ; Gigon, Fabienne ; Verdon, Mélanie ; Annoni, Jean-Marie ; Ricou, Bara

In: Critical Care Medicine, 2014, vol. 42, no. 8, p. 1874–1881

Objectives: Following treatment in an ICU, up to 70% of chronically critically ill patients present neurocognitive impairment that can have negative effects on their quality of life, daily activities, and return to work. The Mini Mental State Examination is a simple, widely used tool for neurocognitive assessment. Although of interest when evaluating ICU patients, the current version is...

Université de Fribourg

Long-term effects of cannabis on brain structure

Battistella, Giovanni ; Fornari, Eleonora ; Annoni, Jean-Marie ; Chtioui, Haithem ; Dao, Kim ; Fabritius, Marie ; Favrat, Bernard ; Mall, Jean-Frédéric ; Maeder, Philippe ; Giroud, Christian

In: Neuropsychopharmacology, 2014, p. -

The dose-dependent toxicity of the main psychoactive component of cannabis in brain regions rich in cannabinoid CB1 receptors is well known in animal studies. However, research in humans does not show common findings across studies regarding the brain regions that are affected after long-term exposure to cannabis. In the present study, we investigate (using Voxel-based Morphometry) gray matter...

Université de Fribourg

White matter in aphasia: A historical review of the Dejerines’ studies

Krestel, Heinz ; Annoni, Jean-Marie ; Jagella, Caroline

In: Brain and Language, 2013, vol. 127, no. 3, p. 526–532

The Objective was to describe the contributions of Joseph Jules Dejerine and his wife Augusta Dejerine-Klumpke to our understanding of cerebral association fiber tracts and language processing. The Dejerines (and not Constantin von Monakow) were the first to describe the superior longitudinal fasciculus/arcuate fasciculus (SLF/AF) as an association fiber tract uniting Broca’s area, Wernicke’s...

Université de Fribourg

THCCOOH concentrations in whole blood: Are they useful in discriminating occasional from heavy smokers?

Fabritius, Marie ; Favrat, Bernard ; Chtioui, Haithem ; Battistella, Giovanni ; Annoni, Jean-Marie ; Appenzeller, Monique ; Dao, Kim ; Fornari, Eleonora ; Lauer, Estelle ; Mall, Jean-Frédéric ; Maeder, Philippe ; Mangin, Patrice ; Staub, Christian ; Giroud, Christian

In: Drug Testing and Analysis, 2013, vol. 6, no. 1-2, p. 155–163

Some forensic and clinical circumstances require knowledge of the frequency of drug use. Care of the patient, administrative, and legal consequences will be different if the subject is a regular or an occasional cannabis smoker. To this end, 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH) has been proposed as a criterion to help to distinguish between these two groups of users. However, to...

Université de Fribourg

Rivastigmine for HIV-associated neurocognitive disorders A randomized crossover pilot study

Simioni, Samanta ; Cavassini, Matthias ; Annoni, Jean-Marie ; Iglesias, Mélanie Métral, Katia ; Abraham, Aline Rimbault ; Jilek, Samantha ; Calmy, Alexandra ; Müller, Hubertus ; Fayet-Mello, Aurélie ; Giacobini, Ezio ; Hirschel, Bernard ; Pasquier, Renaud A. Du

In: Neurology, 2013, vol. 80, no. 6, p. 553–560

Objective: To assess the efficacy and safety of rivastigmine for the treatment of HIV-associated neurocognitive disorders (HAND) in a cohort of long-lasting aviremic HIV+ patients.Methods: Seventeen aviremic HIV+ patients with HAND were enrolled in a randomized, double-blind, placebo-controlled, crossover study to receive either oral rivastigmine (up to 12 mg/day for 20 weeks) followed by placebo...