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Université de Fribourg

A new genus and species for the amiiform fishes previously assigned to Amiopsis from the Early Cretaceous of Las Hoyas, Cuenca, Spain

MartÍn-Abad, Hugo ; Poyato-Ariza, Francisco José

In: Zoological Journal of the Linnean Society, 2017, vol. 181, no. 3, p. 604–637

The Mesozoic actinopterygian fish Amiopsis has been reported from three different localities in the Iberian Peninsula. Amiopsis woodwardi was described from the Berriasian–Valanginian of El Montsec (Lérida, Spain). Isolated vertebral centra referred to Amiopsis were found in the Barremian of Buenache de la Sierra (Cuenca, Spain). Finally, amiiform material from the Barremian of Las Hoyas...

Université de Neuchâtel

The mate-seeking strategies of four braconid parasitoids (Hymenoptera: Braconidae)

Xu, Hao ; Turlings, Ted (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2017.

Parasitic wasps are widely used as biological control agents. To optimize their applications in agriculture, we need to understand how they locate hosts and mate. Parasitic wasps have about 50,000 described species, but less than 30 species have so far been tested in terms of their use of pheromones. In this thesis, I used a combination of bioassays, chemical analyses, and electrophysiological...

Université de Fribourg

Assessment of evolution and risks of glacier lake outbursts in the Djungarskiy Alatau, Central Asia, using Landsat imagery and glacier bed topography modelling

Kapitsa, Vassiliy ; Shahgedanova, Maria ; Machguth, Horst ; Severskiy, Igor ; Medeu, Akhmetkal

In: Nat. Hazards Earth Syst. Sci., 2017, vol. 17, no. 10, p. 1837–1856

Changes in the abundance and area of mountain lakes in the Djungarskiy (Jetysu) Alatau between 2002 and 2014 were investigated using Landsat imagery. The number of lakes increased by 6.2 % from 599 to 636 with a growth rate of 0.51 % a−1. The combined areas were 16.26 ± 0.85 to 17.35 ± 0.92 km2 respectively and the overall change was within the uncertainty of measurements....

Université de Fribourg

Early Miocene gastropod and ectothermic vertebrate remains from the Lesvos Petrified Forest (Greece)

Vasileiadou, Katerina ; Böhme, Madelaine ; Neubauer, Thomas A. ; Georgalis, Georgios L. ; Syrides, George E. ; Papadopoulou, Lambrini ; Zouros, Nickolas

In: PalZ, 2017, vol. 91, no. 4, p. 541–564

The Lesvos Petrified Forest (western Lesvos, Greece) has long been famous for its plant fossils. Recently, one proboscidean (from the Gavathas locality) and seven micromammalian species (from the Lapsarna locality) were described; these were the first animals to be found in the Early Miocene subtropical forest. For the first time, a fauna of gastropods and ectothermic vertebrates from the...

Université de Fribourg

Preliminary observations on the bone histology of the Middle Triassic pseudosuchian archosaur Batrachotomus kupferzellensis reveal fast growth with laminar fibrolamellar bone tissue

Klein, Nicole ; Foth, Christian ; Schoch, Rainer R.

In: Journal of Vertebrate Paleontology, 2017, vol. 37, no. 4, p. e1333121

The bone tissue of femur, rib, and gastralia from three different individuals of the Middle Triassic pseudosuchian Batrachotomus kupferzellensis from southern Germany is studied. The femoral bone tissue comprises laminar fibrolamellar bone tissue throughout and is stratified by three annual growth cycles, indicating that the individual died early in its fourth year of life, at which time it...

Université de Fribourg

In vitro approaches to assess the hazard of nanomaterials

Drasler, Barbara ; Sayre, Phil ; Steinhäuser, Klaus Günter ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: NanoImpact, 2017, vol. 8, no. Supplement C, p. 99–116

The rapid development of engineered nanomaterials demands for a fast and reliable assessment of their health hazard potential. A plethora of experimental approaches have been developed and are widely employed in conventional toxicological approaches. However, the specific properties of nanomaterials such as smaller size but larger surface area, and high catalytic reactivity and distinctive...

Université de Fribourg

Biodistribution of single and aggregated gold nanoparticles exposed to the human lung epithelial tissue barrier at the air-liquid interface

Durantie, Estelle ; Vanhecke, Dimitri ; Rodriguez-Lorenzo, Laura ; Delhaes, Flavien ; Balog, Sandor ; Septiadi, Dedy ; Bourquin, Joel ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Particle and Fibre Toxicology, 2017, vol. 14, p. 49

The lung represents the primary entry route for airborne particles into the human body. Most studies addressed possible adverse effects using single (nano)particles, but aerosolic nanoparticles (NPs) tend to aggregate and form structures of several hundreds nm in diameter, changing the physico-chemical properties and interaction with cells. Our aim was to investigate how aggregation might...

Université de Fribourg

Solid‐phase synthesis of the aged‐nonapeptide‐nerve‐agent adduct of butyrylcholinesterase as reference materials for analytical verification

Bielmann, Andreas ; Curty, Christophe ; Bochet, Christian G.

In: Helvetica Chimica Acta, 2017, vol. 100, no. 11, p. -

Two pathways were developed and investigated for the synthesis of the ‘aged’- nonapeptide nerve-agent bioadduct of human butyrylcholinesterase (BuChE). Considering the fast ageing of nerve-agent adducts of BuChE in patients and biomedical samples this target molecule is of paramount relevance for quantitative analysis with respect to the Chemical Weapons Convention. Two approaches using a ...

Université de Fribourg

A new procyanidin B from Campylospermum zenkeri (Ochnaceae) and antiplasmodial activity of two derivatives of (±)-serotobenine

II, Norbert Mbabi Nyemeck ; Bikobo, Dominique Serge Ngono ; Zintchem, Auguste Abouem A ; Schäfer, Eva-Maria ; Bochet, Christian ; Pegnyemb, Dieudonné Emmanuel ; Koert, Ulrich

In: Natural Product Research, 2017, vol. 31, no. 24, p. 2875–2884

Phytochemical investigation of the stem bark of Campylospermum zenkeri led to the isolation of five known compounds: (Z,Z)-9,12-octadecadienoic acid (1), serotobenine (2), agathisflavone (3), lophirone A (4) and lophirone F (5), together with a new derivative of procyanidin B, a catechin dimer named zenkerinol (6). Serotobenine (2) is structurally related to decursivine which shows moderate...

Université de Fribourg

TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1

Moreno-Torres, Marta ; Jaquenoud, Malika ; Péli-Gulli, Marie-Pierre ; Nicastro, Raffaele ; Virgilio, Claudio De

In: Cell Discovery, 2017, vol. 3, p. 17012

Eukaryotic cell cycle progression through G1–S is driven by hormonal and growth- related signals that are transmitted by the target of rapamycin complex 1 (TORC1) pathway. In yeast, inactivation of TORC1 restricts G1–S transition due to the rapid clearance of G1 cyclins (Cln) and the stabilization of the B-type cyclin (Clb) cyclin- dependent kinase (CDK) inhibitor Sic1. The latter mechanism...