In: Clinical Chemistry and Laboratory Medicine (CCLM), 2016, vol. 54, no. 10, p. 1655-1661
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In: Oncotarget, 2017, vol. 8, no. 69, p. 114393–114413
Microglia cells are the unique residential macrophages of the central nervous system (CNS). They have a special origin, as they derive from the embryonic yolk sac and enter the developing CNS at a very early stage. They play an important role during CNS development and adult homeostasis. They have a major contribution to adult neurogenesis and neuroinflammation. Thus, they participate in the...
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In: Cellular and Molecular Life Sciences CMLS, 2003, vol. 60, no. 12, p. 2547-2560
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In: Brain, 2015, vol. 138, no. 8, p. 2161-2172
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In: Brain, 2012, vol. 135, no. 10, p. 3051-3061
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In: Neuropathology and Applied Neurobiology, 2009, vol. 35, no. 2, p. 165 - 177
Aims: Parenchymal microcalcification in the brain coincides with neurodegenerative diseases, but is also frequently found in neurologically normal individuals. The origin and role of this process are still under debate. Parvalbumin (PV) is a protein acting as a Ca2+ buffer and Ca2+ shuttle towards intracellular Ca2+ sinks, like mitochondria and the endoplasmic reticulum. Constitutively, it is...
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In: Experimental Neurology, 2004, vol. 186, no. 1, p. 78-88
A neuroprotective role for Ca²⁺-binding proteins in neurodegenerative conditions ranging from ischemia to Alzheimer's disease has been suggested in several studies. A key phenomenon in neurodegeneration is the Ca²⁺-mediated excitotoxicity brought about by the neurotransmitter glutamate. To evaluate the relative ability to resist excitotoxicity of neurons containing the slow-onset...
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