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Université de Fribourg

Scan without evidence of dopaminergic deficit: A 10-year retrospective study

Nicastro, Nicolas ; Garibotto, Valentina ; Badoud, Simon ; Burkhard, Pierre R.

In: Parkinsonism & Related Disorders, 2016, vol. 31, p. 53–58

123I-ioflupane SPECT is a powerful method to assess nigrostriatal dopamine system integrity. Several independent studies have shown that 1–15% of patients with suspected degenerative parkinsonism, mainly PD, have scans without evidence of dopaminergic deficit (SWEDD). It has been proposed that most SWEDD patients either present with a non-degenerative condition mimicking PD, such as...

Université de Fribourg

Establishing on-site reference values for 123I-FP-CIT SPECT (DaTSCAN®) using a cohort of individuals with non-degenerative conditions

Nicastro, Nicolas ; Garibotto, Valentina ; Poncet, Antoine ; Badoud, Simon ; Burkhard, Pierre R.

In: Molecular Imaging and Biology, 2016, vol. 18, no. 2, p. 302–312

To overcome the issue of reference values for DaTSCAN® requiring healthy controls, we propose an original approach using scans from individuals with non- degenerative conditions performed at one single center following the same acquisition protocol. Procedures: From a cohort of 970 consecutive patients, we identified 182 patients with a clinical diagnosis of non-degenerative parkinsonism or...