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    Université de Fribourg

    Particle surfaces to study macrophage adherence, migration, and clearance

    Septiadi, Dedy ; Lee, Aaron ; Spuch‐Calvar, Miguel ; Moore, Thomas Lee ; Spiaggia, Giovanni ; Abdussalam, Wildan ; Rodriguez‐Lorenzo, Laura ; Taladriz‐Blanco, Patricia ; Rothen‐Rutishauser, Barbara ; Petri‐Fink, Alke

    In: Advanced Functional Materials, 2020, p. 2002630

    Nanoparticle adsorption to substrates pose a unique challenge to understand uptake mechanisms as it involves the organization of complex cytoskeletal components by cells to perform endocytosis/phagocytosis. In particular, it is not well‐understood from a cell mechanics perspective how the adhesion of particles on substrate will influence the ease of material clearance. By using a particle...

    Université de Fribourg

    Revealing the role of epithelial mechanics and macrophage clearance during pulmonary epithelial injury recovery in the presence of carbon nanotubes

    Septiadi, Dedy ; Abdussalam, Wildan ; Rodriguez‐Lorenzo, Laura ; Spuch‐Calvar, Miguel ; Bourquin, Joël ; Petri‐Fink, Alke ; Rothen‐Rutishauser, Barbara

    In: Advanced Materials, 2018, vol. 30, no. 52, p. 1806181

    Wound healing assays are extensively used to study tissue repair mechanisms; they are typically performed by means of physical (i.e., mechanical, electrical, or optical) detachment of the cells in order to create an open space in which live cells can lodge. Herein, an advanced system based on extensive photobleaching‐induced apoptosis; providing a powerful tool to understand the repair...