In: Chemical Senses, 2010, vol. 35, no. 4, p. 335-346
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In: Chemical Senses, 2006, vol. 32, no. 1, p. 65-89
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In: Frontiers in Behavioral Neuroscience, 2017, vol. 11, p. -
Larval Drosophila offer a study case for behavioral neurogenetics that is simple enough to be experimentally tractable, yet complex enough to be worth the effort. We provide a detailed, hands-on manual for Pavlovian odor-reward learning in these animals. Given the versatility of Drosophila for genetic analyses, combined with the evolutionarily shared genetic heritage with humans, the paradigm...
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In: Journal of Comparative Neurology, 2014, p. –
Drosophila larvae are able to evaluate sensory information based on prior experience, similar to adult flies, other insect species and vertebrates. Larvae and adult flies can be taught to associate odor stimuli with sugar reward and prior work has implicated both the octopaminergic and dopaminergic modulatory systems in reinforcement signaling. Here we use genetics to analyze the anatomy, up to...
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In: PLoS ONE, 2012, vol. 7, no. 10, p. e47518
The Drosophila larva has turned into a particularly simple model system for studying the neuronal basis of innate behaviors and higher brain functions. Neuronal networks involved in olfaction, gustation, vision and learning and memory have been described during the last decade, often up to the single-cell level. Thus, most of these sensory networks are substantially defined, from the sensory...
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In: The Journal of Comparative Neurology, 2012, p. -
The characteristic crawling behavior of Drosophila larvae consists of a series of rhythmic waves of peristalsis and episodes of head swinging and turning. The two biogenic amines octopamine and tyramine have recently been shown to modulate various parameters of locomotion, such as muscle contraction, the time spent in pausing or forward locomotion and the initiation and maintenance of rhythmic...
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In: The Journal of Comparative Neurology, 2011, vol. 59, no. 17, p. 3415–3432
Whereas the “vertical” elements of the insect olfactory pathway, the olfactory receptor neurons and the projection neurons, have been studied in great detail, local interneurons providing “horizontal” connections in the antennal lobe were ignored for a long time. Recent studies in adult Drosophila demonstrate diverse roles for these neurons in the integration of odor information,...
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In: The Journal of Neuroscience, 2010, vol. 30, no. 32, p. 10655-10666
Insect mushroom bodies are required for diverse behavioral functions, including odor learning and memory. Using the numerically simple olfactory pathway of the Drosophila melanogaster larva, we provide evidence that the formation of appetitive olfactory associations relies on embryonic-born intrinsic mushroom body neurons (Kenyon cells). The participation of larval-born Kenyon cells, i.e.,...
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In: Chemical Senses, 2010, vol. 35, no. 4, p. 335-346
Associative plasticity is a basic essential attribute of nervous systems. As shown by numerous reports, Drosophila is able to establish simple forms of appetitive and aversive olfactory associations at both larval and adult stages. Whereas most adult studies on aversive learning employed electric shock as a negative reinforcer, larval paradigms essentially utilized gustatory stimuli to...
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In: Annals of the New York Academy of Sciences, 2009, vol. 1170, p. 482 - 486
Tracing of olfactory projections based on odorant receptor expression has led to an almost complete receptor-to-glomerulus map in adult Drosophila. While most of the glomeruli may be involved in processing of food odors, others appear to be more specialized, for example, responding to CO₂ or to pheromonal cues. Recent studies have shed light on signal processing in the antennal lobe and in...
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