Université de Neuchâtel

Thiolato-bridged arene ruthenium complexes as anticancer agents

Stíbal, David ; Süss-Fink, Georg (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2015.

Cancer is a major cause of morbidity and mortality in today’s world, affecting populations in all countries and all regions. Although no drug or treatment able to cure cancer in all of its forms and variations was found so far, the clinical advancements of 20th and 21st century provided a number of effective drugs for specific types of cancers and had a significant effect...

Université de Neuchâtel

Metallic Ruthenium nanoparticles intercalated in hectorite for highly selective catalytic hydrogenations

Sun, Bing ; Süss-Fink, Georg (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2015.

The design of nanocomposites consisting of functional metals and proper matrices is a very active field of research for the development of recyclable catalysts. Highly active metallic nanoparticles must be stabilized by a suitable support in order to prevent aggregation to bulk metal. Hectorite, a representative smectite clay featured by its unique swelling properties and flexible intercalation...

Université de Neuchâtel

Metallic ruthenium nanoparticles derived from arene ruthenium complexes : synthesis, characterization and applications

Khan, Farooq-Ahmad ; Süss-Fink, Georg (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2012 ; 2247.

The present work deals with the preparation of ruthenium nanoparticles using an organometallic approach. In the first part, the synthesis of ruthenium nanoparticles stabilized by mesogenic isonicotinic ester ligands is presented. We have been interested in the use of long-chain isonicotinic esters as lipohilic components in order to increase the anticancer activity of arene ruthenium...

Université de Neuchâtel

Arene Ruthenium Assemblies for Biological Applications : From Carceplex to Host-Guest Metalla-Cages

Barry, Nicolas ; Süss-Fink, Georg (Dir.) ; Therrien, Bruno (Codir.)

Thèse de doctorat : Université de Neuchâtel, 2011 ; 2192.

Since the development of supramolecular chemistry in the 1980s more and more discrete molecular objects have been synthesised. In this research area metals play a key role. Indeed, the coordination-driven self-assembly allows a directional-bonding approach that organises the different building blocks into supramolecular objects according to the coordination modes of the transition metal....

Université de Neuchâtel

Les complexes arène-ruthénium et polyoxométallates : un lien entre la chimie organométallique et la chimie inorganique

Garcia Fidalgo, Eva ; Süss-Fink, Georg (Dir.)

Thèse de doctorat : Université de Neuchâtel : 2001 ; 1588.

The first part of this work refers to the complexes arene-ruthénium. since their discovery in 1967 by Winkhaus and Singer, the dinuclear arene-ruthenium complexes [(n6 -arène)RuCI2]2, erroneously considered as polymers in the beginning, have been widely used in organometallic chemistry. Very often used in synthesis and homogeneous catalysis, they are easily accessible and perfectly air-stable....

Université de Neuchâtel

New Multifunctional Ligands for the Catalytic Carbonylation of Methanol

Thomas, Christophe ; Süss-Fink, Georg (Dir.)

Thèse de doctorat : Université de Neuchâtel : 2002 ; 1638.

The aim of the present work was to synthesize new multifunctional ligands, to study their coordination properties and to exploit their catalytic potential for the carbonylation of methanol. The carbonylation of methanol to give acetic acid is one of the most important homogeneously catalysed industrial processes. The original [Rh(CO)2I2]- catalyst, developed at the Monsanto laboratories, is...