Université de Neuchâtel

Thiolato-Bridged Arene–Ruthenium Complexes: Synthesis, Molecular Structure, Reactivity, and Anticancer Activity of the Dinuclear Complexes [(arene)2Ru2 (SR)2Cl2]

Ibao, Anne-Flore ; Gras, Michaël ; Therrien, Bruno ; Süss-Fink, Georg ; Zava, Olivier ; Dyson, Paul J.

In: European Journal of Inorganic Chemistry, 2012, vol. 2012, no. 9, p. 1531-1535

Treatment of an arene–ruthenium dichloride dimer with thiols RSH to lead to cationic trithiolato complexes of the type [(arene) 2Ru2(SR)3]+ was shown to proceed through the neutral thiolato complexes [(arene)2Ru2(SR)2Cl2], which have been isolated and characterized for arene =...

Université de Neuchâtel

Thiophenolato-bridged dinuclear arene ruthenium complexes: a new family of highly cytotoxic anticancer agents

Gras, Michaël ; Therrien, Bruno ; Süss-Fink, Georg ; Zava, Olivier ; Dyson, Paul J.

In: Dalton Transactions, 2010, vol. 39, p. 10305-10313

New cationic diruthenium complexes of the type [(arene)2Ru2(SPh)3]+ , arene being C6H6, p-iPrC6H4Me, C6Me6, C6H5R, where R = (CH2)nOC(O)C6H4-p-O(CH2)6CH3 or...

Université de Neuchâtel

Ru2(CO)4(OOCR)2L2 sawhorse-type complexes containing axial 5-(4-pyridyl)-10,15,20-triphenylporphyrin ligands

Gras, Michaël ; Barry, Nicolas P.E. ; Therrien, Bruno ; Süss-Fink, Georg

In: Inorganica Chimica Acta, 2011, vol. 371, no. 1, p. 59-62

The thermal reaction of Ru3(CO)12 with various carboxylic acids (benzoic, 4-hydroxyphenylacetic, ferrocenic, stearic, oleic, 4-(octadecyloxy)benzoic) in refluxing tetrahydrofuran, followed by addition of 5-(4-pyridyl)-10,15,20-triphenylporphyrin (L), gives the dinuclear complexes Ru2(CO)4(OOCR)2L2 (1: R =...

Université de Neuchâtel

Anticancer activity of new organo-ruthenium, rhodium and iridium complexes containing the 2-(pyridine-2-yl)thiazole N,N-chelating ligand

Gras, Michaël ; Süss-Fink, Georg ; Therrien, Bruno ; Casini, Angela ; Edafe , Fabio ; Dyson, Paul J.

In: Journal of Organometallic Chemistry, 2010, vol. 695, no. 8, p. 1119-1125

The dinuclear dichloro complexes [(η6-arene)2Ru2(μ-Cl)2Cl2] and [(η5-C5Me5)2M2 (μ-Cl)2Cl2] react with 2-(pyridine-2-yl)thiazole (pyTz) to afford the cationic complexes [(η6-arene)Ru(pyTz)Cl]+ (arene = C6H61,...

Université de Neuchâtel

Complexes organométalliques mono- et dinucléaires à ligands thiolato et porphyriniques : synthèses, caractérisations et propriétés biologiques

Gras, Michaël ; Süss-Fink, Georg (Dir.) ; Deschenaux, Robert (Codir.)

Thèse de doctorat : Université de Neuchâtel, 2010 ; 2190.

Le but de ce travail de thèse a été de développer dans un premier temps des complexes mononucléaires arène-ruthénium à ligands thiolatopyridine et à ligands chélatants 2-(pyridine-2-yl)thiazaole, puis dans un deuxième temps des complexes dinucléaires arène-ruthénium contenant trois ponts thiophénolato ainsi que des complexes dinucléaires de carbonyle-ruthénium à ponts...

Université de Neuchâtel

Water-soluble arene ruthenium complexes containing pyridinethiolato ligands: Synthesis, molecular structure, redox properties and anticancer activity of the cations [(η6-arene)Ru(p-SC5H4NH)3]2+

Gras, Michaël ; Therrien, Bruno ; Süss-Fink, Georg ; Štěpnička, Petr ; Renfrew, Anna K. ; Dyson, Paul J.

In: Journal of Organometallic Chemistry, 2008, vol. 693, no. 21-22, p. 3419-3424

The cationic complexes [(η6-arene)Ru(SC5H4NH)3]2+, arene being C6H6 (1), MeC6H5 (2), p-iPrC6H4Me (3) or C6Me6 (4), have been synthesised from the reaction of 4-pyridinethiol with the corresponding precursor...