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Impact of CYP2B6 983T>C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients

Wyen, Christoph ; Hendra, Heidy ; Vogel, Martin ; Hoffmann, Christian ; Knechten, Heribert ; Brockmeyer, Norbert H. ; Bogner, Johannes R. ; Rockstroh, Jürgen ; Esser, Stefan ; Jaeger, Hans ; Harrer, Thomas ; Mauss, Stefan ; van Lunzen, Jan ; Skoetz, Nicole ; Jetter, Alexander ; Groneuer, Christiane ; Fätkenheuer, Gerd ; Khoo, Saye H. ; Egan, Deirdre ; Back, David J. ; Owen, Andrew

In: Journal of Antimicrobial Chemotherapy, 2008, vol. 61, no. 4, p. 914-918

Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens

Wyen, Christoph ; Hendra, Heidy ; Siccardi, Marco ; Platten, Martin ; Jaeger, Hans ; Harrer, Thomas ; Esser, Stefan ; Bogner, Johannes R. ; Brockmeyer, Norbert H. ; Bieniek, Bernhard ; Rockstroh, Juergen ; Hoffmann, Christian ; Stoehr, Albrecht ; Michalik, Claudia ; Dlugay, Verena ; Jetter, Alexander ; Knechten, Heribert ; Klinker, Hartwig ; Skaletz-Rorowski, Adriane ; Fätkenheuer, Gerd ; Egan, Deirdre ; Back, David J. ; Owen, Andrew ; Dupke, Stephan ; Carganico, Andreas ; Baumgarten, Axel ; Koeppe, Siegfried ; Kreckel, Peter ; Lauenroth-Mai, Elke ; Schlote, Frank ; Schuler, Christoph ; Freiwald, Matthias ; Rausch, Michael ; Gölz, Jörg ; Moll, Arend ; Zeitz, Martin ; Brockmeyer, Norbert ; Hower, Martin ; Reuter, Stefan ; Harrer, Thomas ; Esser, Stefan ; Staszewski, Schlomo ; Plettenberg, Andreas ; Fenske, Stefan ; Buhk, Thomas ; Stellbrink, Hans-Jürgen ; Schmidt, Reinhold ; Kuhlmann, Birger ; Mosthaf, Franz ; Rieke, Ansgar ; Scholten, Stefan ; Jaeger, Hans ; Jaegel-Guedes, Eva ; Volkert, Ramona ; Becker, Werner ; Hartl, Helmut ; Mutz, Antonius ; Ulmer, Albrecht ; Frietsch, Bernhard ; Müller, Markus

In: Journal of Antimicrobial Chemotherapy, 2011, vol. 66, no. 9, p. 2092-2098

Chronic progressive HIV 1 infection is associated with elevated levels of myeloid derived suppressor cells

Vollbrecht, Thomas ; Stirner, Renate ; Tufman, Amanda ; Roider, Julia ; Huber, Rudolf M. ; Bogner, Johannes R. ; Lechner, Andreas ; Bourquin, Carole ; Draenert, Rika

In: AIDS, 2012, vol. 26, no. 12, p. F31–F37

Objectives: Myeloid-derived suppressor cells (MDSCs) have been described as suppressors of T-cell functions in many tumor models. However, MDSC in HIV-1 infection have not been studied to date. As impaired T-cell function is a hallmark of chronic progressive HIV-1 infection, we hypothesized that MDSC also play a role here.Methods: Surface staining and flow cytometry analysis were performed on...