Université de Fribourg

Lack of parvalbumin in mice leads to behavioral deficits relevant to all human autism core symptoms and related neural morphofunctional abnormalities

Wöhr, M. ; Orduz, D. ; Gregory, Patrick ; Moreno, H ; Khan, U. ; Vörckel, K. J. ; Wolfer, D. P. ; Welzl, H. ; Gall, D. ; Schiffmann, S. N. ; Schwaller, Beat

In: Translational Psychiatry, 2015, vol. 5, no. 3, p. e525

Gene mutations and gene copy number variants are associated with autism spectrum disorders (ASDs). Affected gene products are often part of signaling networks implicated in synapse formation and/or function leading to alterations in the excitation/inhibition (E/I) balance. Although the network of parvalbumin (PV)-expressing interneurons has gained particular attention in ASD, little is known on...

Université de Fribourg

Differences in locomotor behavior revealed in mice deficient for the calcium-binding proteins parvalbumin, calbindin D-28k or both

Farré-Castany, Maria A. ; Schwaller, Beat ; Gregory, Patrick ; Barski, Jaroslaw ; Mariethoz, Céline ; Eriksson, Jan L. ; Tetko, Igor V. ; Wolfer, David ; Celio, Marco R. ; Schmutz, Isabelle ; Albrecht, Urs ; Villa, Alessandro E.P.

In: Behavioural Brain Research, 2007, vol. 178, no. 2, p. 250-261

We investigated the role of the two calcium-binding proteins parvalbumin (PV) and calbindin D-28k (CB) in the locomotor activity and motor coordination using null-mutant mice for PV (PV−/−), CB (CB−/−) or both proteins (PV−/−CB−/−). These proteins are expressed in distinct, mainly non-overlapping populations of neurons of the central and peripheral nervous system and PV...