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Université de Fribourg

Extended-spectrum β-lactamase/AmpC- and carbapenemase-producing Enterobacteriaceae in animals: a threat for humans?

Madec, Jean-Yves ; Haenni, Marissa ; Nordmann, Patrice ; Poirel, Laurent

In: Clinical Microbiology and Infection, 2017, vol. 23, no. 11, p. 826–833

There has been a great and long-term concern that extended-spectrum β-lactamase (ESBL)/AmpC- and carbapenemase-producing Enterobacteriaceae occurring in animals may constitute a public-health issue. A large number of factors with complex interrelations contribute to the spread of those bacteria among animals and humans. ESBL/AmpC- or carbapenemase-encoding genes are most often located on...

Université de Fribourg

Prevalence of faecal carriage of colistin-resistant Gram-negative rods in a university hospital in western France, 2016

Saly, Marion ; Jayol, Aurélie ; Poirel, Laurent ; Megraud, Francis ; Nordmann, Patrice ; Dubois, Véronique

In: Journal of Medical Microbiology, 2017, vol. 66, no. 6, p. 842–843

Plasmid-mediated and chromosomally-encoded colistin resistance is increasingly being reported worldwide. We aimed to determine the prevalence of faecal carriage of colistin-resistant Gram-negative rod isolates in a university hospital in western France. From February to May 2016, rectal swabs from 653 patients hospitalized in various clinical settings were recovered and subsequently screened...

Université de Fribourg

Hafnia, an enterobacterial genus naturally resistant to colistin revealed by three susceptibility testing methods

Jayol, Aurélie ; Saly, Marion ; Nordmann, Patrice ; Ménard, Armelle ; Poirel, Laurent ; Dubois, Véronique

In: Journal of Antimicrobial Chemotherapy, 2017, vol. 72, no. 9, p. 2507–2511

ObjectivesTo determine the susceptibility to colistin of Hafnia alvei and Hafnia paralvei, and to compare methods for colistin resistance detection in the Hafnia genus.MethodsA collection of 25 Hafnia isolates was studied. Species were identified by using 16S rRNA gene sequencing with subsequent phylogeny analysis. Susceptibility to colistin was determined using the broth microdilution (BMD)...

Université de Fribourg

Transposition of Tn1213 encoding the PER-1 Extended Spectrum β-lactamase

Mancini, Stefano ; Poirel, Laurent ; Kieffer, Nicolas ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2018, p. -

PER-1 is an extended-spectrum β-lactamase that is encoded by a gene located into the composite transposon Tn1213 made by two distinct insertion sequences, namely ISPa12 and ISPa13. In vitro mobilization performed in Escherichia coli shows that Tn1213 is functional and is able to mobilize the blaPER-1 gene although at a very low frequency (ca 1x10-9).

Université de Fribourg

Rapid polymyxin NP test for the detection of polymyxin resistance mediated by the MCR-1/MCR-2 genes

Poirel, Laurent ; Larpin, Yu ; Dobias, Jan ; Stephan, Roger ; Decousser, Jean-Winoc ; Madec, Jean-Yves ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2018, vol. 90, no. 1, p. 7–10

The Rapid Polymyxin NP test has been recently developed to rapidly detect polymyxin resistance in Enterobacteriaceae. Here we evaluated this test for detecting MCR- 1/MCR-2-producing Enterobacteriaceae using a collection of 70 non-redundant strains either recovered from the environment, animals, or humans. Sensitivity and specificity were found to be 100%.

Université de Fribourg

Klebsiella pneumoniae co-producing KPC and RmtG, finally targeting Switzerland

Mancini, Stefano ; Poirel, Laurent ; Corthesy, Myriam ; Greub, Gilbert ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2017, p. -

A carbapenem- and pan-aminoglycoside-resistant Klebsiella pneumoniae strain was isolated from a Brazilian patient hospitalized in a Swiss hospital.The clinical isolate carried genes encoding the KPC-2 carbapenemase and the RmtG 16S rRNA methyltransferase.This is the first report of a carbapenem-resistant K. pneumoniae producing RmtG in Europe

Université de Fribourg

High Rate of MCR-1–Producing Escherichia coli and Klebsiella pneumoniae among Pigs, Portugal

Kieffer, Nicolas ; Aires-de-Sousa, Marta ; Nordmann, Patrice ; Poirel, Laurent

In: Emerging Infectious Diseases, 2017, vol. 23, no. 12, p. 2023–2029

The mcr-1 (mobile colistin resistance 1) gene, which encodes phosphoethanolamine transferase, has been recently identified as a source of acquired resistance to polymyxins in Escherichia coli. Using the SuperPolymyxin selective medium, we prospectively screened 100 pigs at 2 farms in Portugal for polymyxin-resistant Enterobacteriaceae and recovered 98 plasmid-mediated MCR-1–producing...

Université de Fribourg

Emergence of an MDR Klebsiella pneumoniae ST231 producing OXA-232 and RmtF in Switzerland

Mancini, Stefano ; Poirel, Laurent ; Tritten, Marie-Lise ; Lienhard, Reto ; Bassi, Cécile ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2017, p. -

The increasing incidence of carbapenem-resistant Klebsiella pneumoniae is a major challenge to public health. Despite the fact that the prevalence of carbapenemases among carbapenem-resistant K. pneumoniae varies geographically, the incidence of OXA-48-like enzymes has soared in recent years and is particularly high in some European countries, such as Spain and France (74% and 78% among ...

Université de Fribourg

Ceftazidime/avibactam alone or in combination with aztreonam against colistin-resistant and carbapenemase-producing Klebsiella pneumoniae

Jayol, Aurélie ; Nordmann, Patrice ; Poirel, Laurent ; Dubois, Véronique

In: Journal of Antimicrobial Chemotherapy, 2017, p. -

The spread of carbapenemase-producing Klebsiella pneumoniae is a major public health concern since such isolates are basically resistant to most available antibiotics, including β-lactams, fluoroquinolones and aminoglycosides.1 Infections due to carbapenemase-producing K. pneumoniae are therefore commonly treated with a regimen containing colistin.1 However, acquired resistance to colistin...