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Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)

Sovari, Sara Nasiri ; Vojnovic, Sandra ; Bogojevic, Sanja Skaro ; Crochet, Aurélien ; Pavic, Aleksandar ; Nikodinovic-Runic, Jasmina ; Zobi, Fabio

In: European Journal of Medicinal Chemistry, 2020, vol. 205, p. 112533

We have prepared a series of ten 3-arylcoumarin molecules, their respective fac- [Re(CO)3(bpy)L]+ and fac-[Re(CO)3(L⁀L)Br] complexes and tested all compounds for their antimicrobial efficacy. Whereas the 3-arylcoumarin ligands are virtually inactive against the human-associated pathogens with minimum inhibitory concentrations (MICs) > 150 μM, when coordinated to the fac-[Re(CO)3]+ core,...