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Developmental regulation of gene expression and astrocytic processes may explain selective hippocampal vulnerability

Lavenex, Pierre ; Sugden, Steven G. ; Davis, Ryan R. ; Gregg, Jeffrey P. ; Lavenex, Pamela Banta

In: Hippocampus, 2010, p. -

The hippocampus plays a central role in the brain network that is essential for memory function. Paradoxically, the hippocampus is also the brain structure that is most sensitive to hypoxic-ischemic episodes. Here, we show that the expression of genes associated with glycolysis and glutamate metabolism in astrocytes and the coverage of excitatory synapses by astrocytic processes undergo...