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Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

Amara, Khaled ; Steen, Johanna ; Murray, Fiona ; Morbach, Henner ; Fernandez-Rodriguez, Blanca M. ; Joshua, Vijay ; Engström, Marianne ; Snir, Omri ; Israelsson, Lena ; Catrina, Anca I. ; Wardemann, Hedda ; Corti, Davide ; Meffre, Eric ; Klareskog, Lars ; Malmström, Vivianne

In: The journal of experimental medicine, 2013, vol. 210, no. 3, p. 445-455

Antibodies targeting citrullinated proteins (ACPAs [anticitrullinated protein antibodies]) are commonly found in patients with rheumatoid arthritis (RA), strongly associate with distinct HLA-DR alleles, and predict a more aggressive disease course as compared with seronegative patients. Still, many features of these antibodies, including their site of production and the extent of MHC class...

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis

Lee, S Hong ; Byrne, Enda M. ; Hultman, Christina M. ; Kähler, Anna ; Vinkhuyzen, Anna AE ; Ripke, Stephan ; Andreassen, Ole A. ; Frisell, Thomas ; Gusev, Alexander ; Hu, Xinli ; Karlsson, Robert ; Mantzioris, Vasilis X. ; McGrath, John J. ; Mehta, Divya ; Stahl, Eli A. ; Zhao, Qiongyi ; Kendler, Kenneth S. ; Sullivan, Patrick F. ; Price, Alkes L. ; O'Donovan, Michael ; Okada, Yukinori ; Mowry, Bryan J. ; Raychaudhuri, Soumya ; Wray, Naomi R. ; Byerley, William ; Cahn, Wiepke ; Cantor, Rita M. ; Cichon, Sven ; Cormican, Paul ; Curtis, David ; Djurovic, Srdjan ; Escott-Price, Valentina ; Gejman, Pablo V. ; Georgieva, Lyudmila ; Giegling, Ina ; Hansen, Thomas F. ; Ingason, Andrés ; Kim, Yunjung ; Konte, Bettina ; Lee, Phil H. ; McIntosh, Andrew ; McQuillin, Andrew ; Morris, Derek W. ; Nöthen, Markus M. ; O'Dushlaine, Colm ; Olincy, Ann ; Olsen, Line ; Pato, Carlos N. ; Pato, Michele T. ; Pickard, Benjamin S. ; Posthuma, Danielle ; Rasmussen, Henrik B. ; Rietschel, Marcella ; Rujescu, Dan ; Schulze, Thomas G. ; Silverman, Jeremy M. ; Thirumalai, Srinivasa ; Werge, Thomas ; Agartz, Ingrid ; Amin, Farooq ; Azevedo, Maria H. ; Bass, Nicholas ; Black, Donald W. ; Blackwood, Douglas H R. ; Bruggeman, Richard ; Buccola, Nancy G. ; Choudhury, Khalid ; Cloninger, Robert C. ; Corvin, Aiden ; Craddock, Nicholas ; Daly, Mark J. ; Datta, Susmita ; Donohoe, Gary J. ; Duan, Jubao ; Dudbridge, Frank ; Fanous, Ayman ; Freedman, Robert ; Freimer, Nelson B. ; Friedl, Marion ; Gill, Michael ; Gurling, Hugh ; De Haan, Lieuwe ; Hamshere, Marian L. ; Hartmann, Annette M. ; Holmans, Peter A. ; Kahn, René S. ; Keller, Matthew C. ; Kenny, Elaine ; Kirov, George K. ; Krabbendam, Lydia ; Krasucki, Robert ; Lawrence, Jacob ; Lencz, Todd ; Levinson, Douglas F. ; Lieberman, Jeffrey A. ; Lin, Dan-Yu ; Linszen, Don H. ; Magnusson, Patrik KE ; Maier, Wolfgang ; Malhotra, Anil K. ; Mattheisen, Manuel ; Mattingsdal, Morten ; McCarroll, Steven A. ; Medeiros, Helena ; Melle, Ingrid ; Milanova, Vihra ; Myin-Germeys, Inez ; Neale, Benjamin M. ; Ophoff, Roel A. ; Owen, Michael J. ; Pimm, Jonathan ; Purcell, Shaun M. ; Puri, Vinay ; Quested, Digby J. ; Rossin, Lizzy ; Ruderfer, Douglas ; Sanders, Alan R. ; Shi, Jianxin ; Sklar, Pamela ; St. Clair, David ; Stroup, T Scott ; Van Os, Jim ; Visscher, Peter M. ; Wiersma, Durk ; Zammit, Stanley ; Bridges, S Louis ; Choi, Hyon K. ; Coenen, Marieke JH ; de Vries, Niek ; Dieud, Philippe ; Greenberg, Jeffrey D. ; Huizinga, Tom WJ ; Padyukov, Leonid ; Siminovitch, Katherine A. ; Tak, Paul P. ; Worthington, Jane ; De Jager, Philip L. ; Denny, Joshua C. ; Gregersen, Peter K. ; Klareskog, Lars ; Mariette, Xavier ; Plenge, Robert M. ; van Laar, Mart ; van Riel, Piet

In: International Journal of Epidemiology, 2015, vol. 44, no. 5, p. 1706-1721