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RACK1 is an interaction partner of ATG5 and a novel regulator of autophagy

Erbil, Secil ; Oral, Ozlem ; Mitou, Geraldine ; Kig, Cenk ; Durmaz-Timucin, Emel ; Guven-Maiorov, Emine ; Gulacti, Ferah ; Gokce, Gokcen ; Dengjel, Jörn ; Sezerman, Osman Ugur ; Gozuacik, Devrim

In: Journal of Biological Chemistry, 2016, vol. 291, no. 32, p. 16753–16765

Autophagy is biological mechanism allowing recycling of long-lived proteins, abnormal protein aggregates, and damaged organelles under cellular stress conditions. Following sequestration in double- or multimembrane autophagic vesicles, the cargo is delivered to lysosomes for degradation. ATG5 is a key component of an E3-like ATG12-ATG5-ATG16 protein complex that catalyzes conjugation of the...