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Discovery of a 29-gene panel in peripheral blood mononuclear cells for the detection of colorectal cancer and adenomas using high throughput real-time PCR

Ciarloni, Laura ; Hosseinian, Sahar ; Monnier-Benoit, Sylvain ; Imaizumi, Natsuko ; Dorta, Gian ; Rüegg, Curzio

In: PLoS ONE, 2015, vol. 10, no. 4, p. e0123904

Colorectal cancer (CRC) is the second leading cause of cancer-related death in developed countries. Early detection of CRC leads to decreased CRC mortality. A blood-based CRC screening test is highly desirable due to limited invasiveness and high acceptance rate among patients compared to currently used fecal occult blood testing and colonoscopy. Here we describe the discovery and validation...