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Université de Fribourg

Dextran sulfate modulates MAP kinase signaling and reduces endothelial injury in a rat aortic clamping model

Banz, Yara ; Gajanayake, Thusitha ; Matozan, Katja ; Yang, Zhihong ; Rieben, Robert

In: Journal of Vascular Surgery, 2009, vol. 50, no. 1, p. 161-170

Objective: Mitogen-activated protein kinases (MAPKs), including JNK, p38, and ERK1/2, noticeably influence ischemia/reperfusion injury (IRI). The complement inhibitor dextran sulfate (DXS) associates with damaged endothelium denudated of its heparan sulfate proteoglycan (HSPG) layer. Other glycosaminoglycan analogs are known to influence MAPK signaling. Hypothetically therefore, targeted...