Université de Fribourg

NONO couples the circadian clock to the cell cycle

Kowalska, Elzbieta ; Ripperger, Jürgen A. ; Hoegger, Dominik C. ; Bruegger, Pascal ; Buch, Thorsten ; Birchler, Thomas ; Mueller, Anke ; Albrecht, Urs ; Contaldo, Claudio ; Brown, Steven A.

In: Proceedings of the National Academy of Sciences - PNAS, 2013, vol. 110, no. 5, p. 1592-1599

Mammalian circadian clocks restrict cell proliferation to defined time windows, but the mechanism and consequences of this interrelationship are not fully understood. Previously we identified the multifunctional nuclear protein NONO as a partner of circadian PERIOD (PER) proteins. Here we show that it also conveys circadian gating to the cell cycle, a connection surprisingly important for...

Université de Fribourg

Distinct roles of DBHS family members in the circadian transcriptional feedback loop

Kowalska, Elzbieta ; Ripperger, Jürgen A. ; Muheim, Christine ; Maier, Bert ; Kurihara, Yasuyuki ; Fox, Archa H. ; Kramer, Achim ; Brown, Steven A.

In: Molecular and Cellular Biology, 2012, p. -

Factors interacting with core circadian clock components are essential to achieve transcriptional feedback necessary for metazoan clocks. Here we show that all three members of the Drosophila Behavior Human Splicing (DBHS) family of RNA-binding proteins play a role in the mammalian circadian oscillator, abrogating or altering clock function when overexpressed or depleted in cells. Although these...