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Université de Fribourg

Increased uptake of silica nanoparticles in inflamed macrophages but not upon co-exposure to micron-sized particles

Susnik, Eva ; Taladriz-Blanco, Patricia ; Drasler, Barbara ; Balog, Sandor ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Cells, 2020, vol. 9, no. 9, p. 2099

Silica nanoparticles (NPs) are widely used in various industrial and biomedical applications. Little is known about the cellular uptake of co-exposed silica particles, as can be expected in our daily life. In addition, an inflamed microenvironment might affect a NP’s uptake and a cell’s physiological response. Herein, prestimulated mouse J774A.1 macrophages with bacterial...

Université de Fribourg

Characterization of the shape anisotropy of superparamagnetic iron oxide nanoparticles during thermal decomposition

Vanhecke, Dimitri ; Crippa, Federica ; Lattuada, Marco ; Balog, Sandor ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Materials, 2020, vol. 13, no. 9, p. 2018

Magnetosomes are near-perfect intracellular magnetite nanocrystals found in magnetotactic bacteria. Their synthetic imitation, known as superparamagnetic iron oxide nanoparticles (SPIONs), have found applications in a variety of (nano)medicinal fields such as magnetic resonance imaging contrast agents, multimodal imaging and drug carriers. In order to perform these functions in medicine,...

Université de Fribourg

Use of EpiAlveolar lung model to predict fibrotic potential of multiwalled carbon nanotubes

Barosova, Hana ; Maione, Anna G. ; Septiadi, Dedy ; Sharma, Monita ; Haeni, Laetitia ; Balog, Sandor ; O’Connell, Olivia ; Jackson, George R. ; Brown, David ; Clippinger, Amy J. ; Hayden, Patrick ; Petri-Fink, Alke ; Stone, Vicki ; Rothen-Rutishauser, Barbara

In: ACS Nano, 2020, vol. 14, no. 4, p. 3941–3956

Expansion in production and commercial use of nanomaterials increases the potential human exposure during the lifecycle of these materials (production, use, and disposal). Inhalation is a primary route of exposure to nanomaterials; therefore it is critical to assess their potential respiratory hazard. Herein, we developed a three-dimensional alveolar model (EpiAlveolar) consisting of human...

Université de Fribourg

Versatile macroscale concentration gradients of nanoparticles in soft nanocomposites

Taladriz‐Blanco, Patricia ; Rothen‐Rutishauser, Barbara ; Petri‐Fink, Alke ; Balog, Sandor

In: Small, 2020, vol. 16, no. 6, p. 1905192

Nanocomposite materials benefit from the diverse physicochemical properties featured by nanoparticles, and the presence of nanoparticle concentration gradients can lend functions to macroscopic materials beyond the realm of classical nanocomposites. It is shown here that linearity and time‐shift invariance obtained via the synergism of two independent physical phenomena—translational...

Université de Fribourg

Simple and fast evaluation of relaxation parameters of magnetic nanoparticles

Lemal, Philipp ; Balog, Sandor ; Ackermann-Hirschi, Liliane ; Taladriz-Blanco, Patricia ; Hirt, Ann M. ; Rothen-Rutishauser, Barbara ; Lattuada, Marco ; Petri-Fink, Alke

In: Journal of Magnetism and Magnetic Materials, 2020, vol. 499, p. 166176

The efficacy of magnetic hyperthermia treatment depends on the optimal available magnetic nanoparticles (MNPs) that are excited in a given alternating magnetic field and viscosity of the region of interest. In this regard, assessing the relevant relaxation parameters is of upmost importance and could improve the speed of development of efficient applications. Here, we demonstrate how to...

Université de Fribourg

Resolution limit of taylor dispersion: an exact theoretical study

Taladriz-Blanco, Patricia ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke ; Balog, Sandor

In: Analytical Chemistry, 2020, vol. 92, no. 1, p. 561–566

Taylor dispersion is a microfluidic analytical technique with a high dynamic range and therefore is suited well to measuring the hydrodynamic radius of small molecules, proteins, supramolecular complexes, macromolecules, nanoparticles and their self- assembly. Here we calculate an unaddressed yet fundamental property: the limit of resolution, which is defined as the smallest change in the...

Université de Fribourg

Preparation of metallosupramolecular single-chain polymeric nanoparticles and their characterization by Taylor dispersion

Neumann, Laura N. ; Urban, Dominic A. ; Lemal, Philipp ; Ramani, Sushila ; Petri-Fink, Alke ; Balog, Sandor ; Weder, Christoph ; Schrettl, Stephen

In: Polymer Chemistry, 2020, vol. 11, no. 2, p. 586–592

Intramolecular cross-linking of polymers can furnish single-chain polymeric nanoparticles (SCPNs), and the use of reversible non-covalent bonds for cross-linking can potentially provide such nanoparticles with stimuli-responsive properties. Here, we report the synthesis of acrylic polymers that carry pendant 2,6-bis(1′-methyl- benzimidazolyl)pyridine ligands, and use these for the...

Université de Fribourg

Polydopamine nanoparticle doped nanofluid for solar thermal energy collector efficiency increase

Hauser, Daniel ; Steinmetz, Lukas ; Balog, Sandor ; Taladriz‐Blanco, Patricia ; Septiadi, Dedy ; Wilts, Bodo D. ; Petri‐Fink, Alke ; Rothen‐Rutishauser, Barbara

In: Advanced Sustainable Systems, 2020, vol. 4, no. 1, p. 1900101

Polydopamine can form black nanoparticles and has recently been gaining attention due to its extraordinary heating properties upon excitation with light. Herein, polydopamine hybrid nanoparticles are synthesized in different sizes and subsequently added to a solar fluid to analyze heating ability. The solar fluids with the differently sized hybrid polydopamine particles are compared to a...

Université de Fribourg

The influence of substituents on gelation and stacking order of oligoaramid – based supramolecular networks

Drechsler, Susanne ; Balog, Sandor ; Kilbinger, Andreas F. M. ; Casalini, Tommaso

In: Soft Matter, 2019, vol. 15, no. 36, p. 7250–7261

Self-assembly has proven to be a powerful tool for functional, smart materials such as hydrogels derived from low molecular weight compounds. However, the targeted design of functional gelators remains difficult. Here, we present a set of four Y-shaped aromatic amide tetramers with varying functionalities able to undergo different non- covalent interactions. These compounds were explored...

Université de Fribourg

Precision of Taylor dispersion

Taladriz-Blanco, Patricia ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke ; Balog, Sandor

In: Analytical Chemistry, 2019, vol. 91, no. 15, p. 9946–9951

Taylor dispersion is capable of measuring accurately the hydrodynamic radius over several orders of magnitude. Accordingly, it is now a highly competitive technique dedicated to characterizing small molecules, proteins, macromolecules, nanoparticles, and their self-assembly. Regardless, an in-depth analysis addressing the precision of the technique, being a key indicator of reproducibility,...