In: The Journal of Physical Chemistry B, 2009, vol. 113, no. 6, p. 1693–1709
We present a study of binary mixtures of eye lens crystallin proteins. A coarse-grained model of aqueous α- and γ-crystallin mixtures based on molecular dynamics simulations and SANS experiments is proposed. Thermodynamic perturbation theory is implemented to obtain the stability boundaries, or spinodal surface, of the binary mixture in the full parameter space. The stability of these...
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In: Physical Review Letters, 2007, vol. 99, no. 19, p. 198103
Small-angle neutron scattering experiments and molecular dynamics simulations combined with an application of concepts from soft matter physics to complex protein mixtures provide new insight into the stability of eye lens protein mixtures. Exploring this colloid-protein analogy we demonstrate that weak attractions between unlike proteins help to maintain lens transparency in an extremely...
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