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Université de Neuchâtel

Postmortem biochemistry performed on vitreous humor after postmortem CT-angiography

Grabherr, Silke ; Widmer, Christèle ; Iglesias, Katia ; Sporkert, Frank ; Augsburger, Marc ; Mangin, Patrice ; Palmiere, Cristian

In: Legal Medicine, 2012, vol. 14, no. 6, p. 297-303

Postmortem angiography is becoming increasingly essential in forensic pathology as an adjunct to conventional autopsy. Despite the numerous advantages of this technique, some questions have been raised regarding the influence of the contrast agent injected on the results of toxicological and biochemical analyses. The aim of this study was to investigate the effect of the injection of the contrast...

Université de Neuchâtel

Biochemical markers of fatal hypothermia

Palmiere, Cristian ; Bardy, Daniel ; Letovanec, Igor ; Mangin, Patrice ; Augsburger, Marc ; Ventura, Francesco ; Iglesias, Katia ; Werner, Dominique

In: Forensic Science International, 2013, vol. 226, no. 1-3, p. 54-61

The aim of this study was to investigate the usefulness of postmortem biochemical investigations in the diagnosis of fatal hypothermia. 10 cases of fatal hypothermia and 30 control cases were selected. A series of biochemical parameters, such as glucose, acetone, 3-beta-hydroxybutyrate, isopropyl alcohol, free fatty acids, adrenaline, growth hormone, adrenocorticotropic hormone,...

Université de Neuchâtel

Procalcitonin and C-reactive protein in pericardial fluid for postmortem diagnosis of sepsis

Schrag, Bettina ; Iglesias, Katia ; Mangin, Patrice ; Palmiere, Cristian

In: International Journal of Legal Medicine, 2012, vol. 126, no. 4, p. 567-572

The aim of this study was to investigate the presence and concentrations of procalcitonin and C-reactive protein in pericardial fluid and compare these levels to those found in the postmortem serum obtained from the femoral blood. Two groups were formed, a sepsis-related fatalities group and a control group. Postmortem native CT scans, autopsies, histology, neuropathology and toxicology as well...

Université de Neuchâtel

Diagnostic value of lipopolysaccharide-binding protein and procalcitonin for sepsis diagnosis in forensic pathology

Augsburger, Marc ; Iglesias, Katia ; Bardy, Daniel ; Mangin, Patrice ; Palmiere, Cristian

In: International Journal of Legal Medicine, 2013, vol. 127, no. 2, p. 427-435

The aims of this study were twofold. The first was to investigate the diagnostic performance of two biochemical markers, procalcitonin (PCT) and lipopolysaccharide-binding protein (LBP), considering each individually and then combined, for the postmortem diagnosis of sepsis. We also tested the usefulness of pericardial fluid for postmortem LBP determination. Two study groups were formed, a...

Université de Fribourg

THCCOOH concentrations in whole blood: Are they useful in discriminating occasional from heavy smokers?

Fabritius, Marie ; Favrat, Bernard ; Chtioui, Haithem ; Battistella, Giovanni ; Annoni, Jean-Marie ; Appenzeller, Monique ; Dao, Kim ; Fornari, Eleonora ; Lauer, Estelle ; Mall, Jean-Frédéric ; Maeder, Philippe ; Mangin, Patrice ; Staub, Christian ; Giroud, Christian

In: Drug Testing and Analysis, 2013, vol. 6, no. 1-2, p. 155–163

Some forensic and clinical circumstances require knowledge of the frequency of drug use. Care of the patient, administrative, and legal consequences will be different if the subject is a regular or an occasional cannabis smoker. To this end, 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH) has been proposed as a criterion to help to distinguish between these two groups of users. However, to...