In: Nature Chemistry, 2015, vol. 7, no. 9, p. 718–723
In living ring-opening metathesis polymerization (ROMP), a transition-metal–carbene complex polymerizes ring-strained olefins with very good control of the molecular weight of the resulting polymers. Because one molecule of the initiator is required for each polymer chain, however, this type of polymerization is expensive for widespread use. We have now designed a chain-transfer agent (CTA)...
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In: Physical Chemistry Chemical Physics, 2015, vol. 17, no. 6, p. 4696–4700
The effect which deformation of the double bond in trans-cyclooctene (TCO), compared to cis-cyclooctene (CCO), has on its negative ion – and indirectly on the π* virtual orbital – was studied by electron-impact spectroscopy. Differential elastic and vibrational excitation cross sections were measured at a scattering angle of θ = 135°. The vertical attachment energy (VAE) derived from the...
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In: Angewandte Chemie International Edition, 2014, vol. 53, no. 46, p. 12613–12617
The functionalization of gold nanorods (GNRs) with polymers is essential for both their colloidal stability and biocompatibility. However, a bilayer of the toxic cationic surfactant cetyl trimethylammonium bromide (CTAB) adsorbed on the nanorods complicates this process. Herein, we report on a strategy for the biocompatible functionalization of GNRs with a hydrophobic polymeric precursor,...
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In: Journal of the American Chemical Society, 2014, vol. 136, no. 37, p. 12832–12835
Macrocyclizations in exceptionally good yields were observed during the self-condensation of N-benzylated phenyl p-aminobenzoates in the presence of LiHMDS to yield three-membered cyclic aramides that adopt a triangular shape. An ortho-alkyloxy side chain on the N-benzyl protecting group is necessary for the macrocyclization to occur. Linear polymers are formed exclusively in the absence of this...
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In: CHIMIA International Journal for Chemistry, 2013, vol. 67, no. 11, p. 788–790
We present the solid-supported synthesis of a linear rigid rod-like tetradeca(p-benzamide) nanorod as well as a pentadeca( p -benzamide) nanorod carrying an amide N-hexyl side chain at the center of the rod (on the 8th amino acid of the molecule). These nanorods were conjugated with solubilizing poly(ethylene glycol) chains and their solution aggregation was investigated. Both rod–coil block...
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In: ACS Nano, 2013, vol. 7, no. 6, p. 5491–5498
Molecular self-assembly on surfaces is dictated by the delicate balance between intermolecular and molecule–surface interactions. For many insulating surfaces, however, the molecule–surface interactions are weak and rather unspecific. Enhancing these interactions, on the other hand, often puts a severe limit on the achievable structural variety. To grasp the full potential of molecular...
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In: Macromolecules, 2012, p. -
The ring-opening metathesis polymerization using ruthenium carbene initiators developed by Grubbs et al. is one of the most functional group tolerant living polymerization methods known. One of the most used postpolymerization functionalization methods used today is the copper-catalyzed 1,3-dipolar cycloaddition between alkynes and organic azides. Organic azides are, however, not tolerated by...
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In: Macromolecules, 2012, vol. 45, no. 11, p. 4447–4453
An efficient strategy for the synthesis of monoamine end-functionalized living polymers using ring-opening metathesis polymerization with ruthenium initiators is reported. A new end-capping agent for this purpose was synthesized, and its efficiency for end-functionalization was evaluated using two common ruthenium-based initiators. Finally, terminal cross-metathesis was also explored as...
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In: Acta Crystallographica Section B, 2012, vol. 68, no. 2, p. 171-181
Ab-initio crystal structure analysis of organic materials from electron diffraction data is presented. The data were collected using the automated electron diffraction tomography (ADT) technique. The structure solution and refinement route is first validated on the basis of the known crystal structure of tri-p-benzamide. The same procedure is then applied to solve the previously unknown crystal...
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In: Antimicrobial Agents and Chemotherapy, 2012, vol. 56, no. 15, p. 75-82
Polyethylenimines are cationic polymers with potential as delivery vectors in gene therapy and with proven antimicrobial activity. However, the antiviral activity of polyethylenimines has not been addressed in detail thus far. We have studied the inhibitory effects of a linear 25-kDa polyethylenimine on infections with human papillomaviruses and human cytomegaloviruses. Preincubation of cells...
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