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Université de Fribourg

Temocillin and piperacillin/tazobactam resistance by disc diffusion as antimicrobial surrogate markers for the detection of carbapenemase-producing Enterobacteriaceae in geographical areas with a high prevalence of OXA-48 producers

Huang, Te-Din ; Poirel, Laurent ; Bogaerts, Pierre ; Berhin, Catherine ; Nordmann, Patrice ; Glupczynski, Youri

In: Journal of Antimicrobial Chemotherapy, 2014, vol. 69, no. 2, p. 445–450

Objectives To assess the performance of the agar disc diffusion method for the detection of carbapenemase-producing Enterobacteriaceae (CPE) referred to the national reference laboratories (NRLs) in Belgium and France.Methods All Enterobacteriaceae isolates referred to the NRLs for the confirmation of CPE in 2012 were included. The inhibition zone diameters of...

Université de Fribourg

Derepressed transfer properties leading to the efficient spread of the plasmid encoding carbapenemase OXA-48

Potron, Anaïs ; Poirel, Laurent ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2013, vol. 58, no. 1, p. 467–471

The current emergence of the carbapenemase OXA-48 among Enterobacteriaceae is related to the spread of a single IncL/M-type plasmid, pOXA-48a. This plasmid harbors the blaOXA-48 gene within a composite transposon, Tn1999, which is inserted into the tir gene, encoding a transfer inhibition protein. We showed that the insertion of Tn1999 into the...

Université de Fribourg

Outbreak of NDM-1-producing Acinetobacter baumannii in France, January to May 2013

Decousser, J. W. ; Jansen, C. ; Nordmann, Patrice ; Emirian, A . ; Bonnin, R. A. ; Anais, L. ; Merle, J. C. ; Poirel, Laurent

In: Eurosurveillance, 2013, vol. 18, no. 31, p. 20547

We report the first outbreak of carbapenem-resistant NDM-1-producing Acinetobacter baumannii in Europe, in a French intensive-care unit in January to May 2013. The index patient was transferred from Algeria and led to the infection/colonisation of five additional patients. Concurrently, another imported case from Algeria was identified. The seven isolates were genetically indistinguishable,...

Université de Fribourg

Intercontinental spread of oxa-48 beta-lactamase-producing enterobacteriaceae over a 11-year period, 2001 to 2011

Potron, A. ; Poirel, Laurent ; Rondinaud, E.

In: Eurosurveillance, 2013, vol. 18, no. 31, p. 20549

OXA-48 beta-lactamase producers are emerging as an important threat mostly in the Mediterranean area. We report here the molecular epidemiology of a collection of OXA-48 beta-lactamase-positive enterobacterial isolates (n=107) recovered from European and north-African countries between January 2001 and December 2011. This collection included 67 Klebsiella pneumoniae, 24 Escherichia coli and 10...

Université de Fribourg

Carbapenemase-producing enterobacteriaceae in Europe: a survey among national experts from 39 countries, february 2013

Glasner, C. ; Albiger, B. ; Buist, G. ; Tambić Andrašević, A. ; Canton, R. ; Carmeli, Y. ; Friedrich, A. W. ; Giske, C. G. ; Glupczynski, Y. ; Gniadkowski, M. ; Livermore, D. M. ; Nordmann, Patrice ; Poirel, Laurent ; Rossolini, G. M. ; Seifert, H. ; Vatopoulos, A. ; Walsh, T. ; Woodford, N. ; Donker, T. ; Monnet, D. L. ; Grundmann, H. ; group, the European Survey on Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) working

In: Euro Surveillance, 2013, vol. 18, no. 28, p. 20525

The spread of carbapenemase-producing Enterobacteriaceae (CPE) is a threat to healthcare delivery, although its extent differs substantially from country to country. In February 2013, national experts from 39 European countries were invited to self-assess the current epidemiological situation of CPE in their country. Information about national management of CPE was also reported. The results...

Université de Fribourg

Strategy for a rapid detection of carbapenemase-producing Enterobacteriaceae

Dortet, Laurent ; Bréchard, Ludivine ; Cuzon, Gaëlle ; Poirel, Laurent ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2014, vol. 58, no. 4, p. 2441-2445

A prospective survey was conducted on 862 Enterobacteriaceae with reduced susceptibility to carbapenems. The Carba NP test, UV spectrophotometry and DNA microarray were used for detecting carbapenemase producers, and results compared to PCR and sequencing. The 172 carbapenemase producers were detected using the Carba NP test and UV spectrophotometry whereas DNA microarray failed to detect IMI...

Université de Fribourg

Bloodstream infections caused by Pseudomonas spp.; how to detect carbapenemase producers directly from positive blood cultures ?

Dortet, Laurent ; Boulanger, Anne ; Poirel, Laurent ; Nordmann, Patrice

In: Journal of Clinical Microbiology, 2014, vol. 52, no. 4, p. 1269–1273

The Carba NP test has been evaluated to detect carbapenemase-producing Pseudomonas spp. directly from blood cultures. This rapid and cost-effective test permits an early identification of carbapenemase-producing Pseudomonas spp. directly from blood cultures with excellent sensitivity and specificity. Results may be useful in particular for guiding the first-line therapy and epidemiological...

Université de Fribourg

New Delhi metallo-β-lactamase-producing Acinetobacter baumannii : a novel paradigm for spreading antibiotic resistance genes

Bonnin, Rémy A ; Poirel, Laurent ; Nordmann, 2 Patrice

In: Future Microbiology, 2013, vol. 9, no. 1, p. 33–41

The impact of carbapenemase production among clinically significant Gram-negative rods is becoming a major medical issue. To date, Acinetobacter baumannii has been considered as a final recipient of carbapenemase genes (imipenemase, Verona metallo-β-lactamase, Guiana extended-spectrum β-lactamase and Klebsiella pneumonia carbapenemase types) from Enterobacteriaceae and...