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Université de Fribourg

Discrete coding of reward probability and uncertainty by dopamine neurons

Fiorillo, Christopher D. ; Tobler, Philippe N ; Schultz, Wolfram

In: Science, 2005, vol. 299, no. 5614, p. 1898 - 1902

Uncertainty is critical in the measure of information and in assessing the accuracy of predictions. It is determined by probability P, being maximal at P = 0.5 and decreasing at higher and lower probabilities. Using distinct stimuli to indicate the probability of reward, we found that the phasic activation of dopamine neurons varied monotonically across the full range of...

Université de Fribourg

Adaptive coding of reward value by dopamine neurons

Tobler, Philippe N. ; Fiorillo, Christopher D. ; Schultz, Wolfram

In: Science, 2001, vol. 307, no. 5715, p. 1642-1645

It is important for animals to estimate the value of rewards as accurately as possible. Because the number of potential reward values is very large, it is necessary that the brain's limited resources be allocated so as to discriminate better among more likely reward outcomes at the expense of less likely outcomes. We found that midbrain dopamine neurons rapidly adapted to the information provided...

Université de Fribourg

Target neuron prespecification in the olfactory map of Drosophila

Jefferis, Gregory S. X. E. ; Marin, Elizabeth C. ; Stocker, Reinhard F. ; Luo, Liqun

In: Nature, 2001, vol. 414, p. 204-208

In Drosophila and mice, olfactory receptor neurons (ORNs) expressing the same receptors have convergent axonal projections to specific glomerular targets in the antennal lobe/olfactory bulb, creating an odour map in this first olfactory structure of the central nervous system1, 2, ³. Projection neurons of the Drosophila antennal lobe send dendrites into...

Université de Fribourg

Influence of TOR kinase on lifespan in C. elegans

Vellai, Tibor ; Takacs-Vellai, Krisztina ; Zhang, Yue ; Kovacs, Attila L. ; Orosz, László ; Müller, Fritz

In: Nature, 2003, vol. 426, p. 620

The group of enzymes known as TOR (for 'target of rapamycin') kinases regulates cell growth and proliferation in response to nutrients and hormone-dependent mitogenic signals1, 2. Here we show that TOR deficiency in the nematode Caenorhabditis elegans more than doubles its natural lifespan. This new function for TOR signalling in ageing control may represent a link between...

Université de Fribourg

A selective advantage to immigrant genes in a Daphnia metapopulation

Ebert, Dieter ; Haag, Christoph ; Kirkpatrick, Mark ; Riek, Myriam ; Hottinger, Jürgen W. ; Pajunen, V. Ilmari

In: Science 295(5554): 485 - 488, 2002, 2002, vol. 295, no. 5554, p. 485-488

Immigrants to habitats occupied by conspecific organisms are usually expected to be competitively inferior, because residents may be locally adapted. If residents are inbred, however, mating between immigrants and residents results in offspring that may enjoy a fitness advantage from hybrid vigor. We demonstrate this effect experimentally in a natural Daphnia metapopulation in which...

Université de Fribourg

Correlation between thermodynamical stabilities of metal borohydrides and cation electronegativites: First-principles calculations and experiments

Nakamori, Yuko ; Miwa, Kazutoshi ; Ninomiya, Akihito ; Li, Haiwen ; Ohba, Nobuko ; Towata, Shin-ichi ; Züttel, Andreas ; Orimo, Shin-ichi

In: Physical Review B, 2006, vol. 74, p. 045126

The thermodynamical stabilities for the series of metal borohydrides M(BH₄)n (M=Li, Na, K, Cu, Mg, Zn, Sc, Zr, and Hf; n=1–4) have been systematically investigated by first-principles calculations. The results indicated that an ionic bonding between Mⁿ⁺ cations and [BH₄]⁻ anions exists in M(BH₄)n, and the charge...

Université de Fribourg

Spinodal decomposition in a food colloid–biopolymer mixture: evidence for a linear regime

Bhat, Suresh ; Tuinier, Remco ; Schurtenberger, Peter

In: Journal of Physics: Condensed Matter, 2006, vol. 18, p. L339–L346

We investigate phase separation and structural evolution in a complex food colloid (casein micelles) and biopolymer (xanthan) mixture using small-angle light scattering. We demonstrate that phase separation is induced by a depletion mechanism, and that the resulting coexistence curve can be described by osmotic equilibrium theory for mixtures of colloids and polymer chains in a background...

Université de Fribourg

Renormalization in charged colloids: non-monotonic behaviour with the surface charge

Haro-Pérez, C. ; Quesada-Pérez, M. ; Callejas-Fernández, J. ; Schurtenberger, Peter ; Hidalgo-Álvarez, R.

In: Journal of Physics: Condensed Matter, 2006, vol. 18, p. L363-L369

The static structure factor S(q) is measured for a set of deionized latex dispersions with different numbers of ionizable surface groups per particle and similar diameters. For a given volume fraction, the height of the main peak of S(q), which is a direct measure of the spatial ordering of latex particles, does not increase monotonically with the number of ionizable...

Université de Fribourg

Quantum statistics of interacting dimer spin systems

Rüegg, Ch. ; Normand, Bruce ; Matsumoto, M. ; Niedermayer, Ch. ; Furrer, A. ; Krämer, K. W. ; Güdel, Hans-Ulrich ; Bourges, Ph. ; Sidis, Y. ; Mutka, H.

In: Physical Review Letters, 2006, vol. 95, p. 267201

The compound TlCuCl₃ represents a model system of dimerized quantum spins with strong interdimer interactions. We investigate the triplet dispersion as a function of temperature by inelastic neutron scattering experiments on single crystals. By comparison with a number of theoretical approaches we demonstrate that the description of Troyer, Tsunetsugu, and Würtz [Phys. Rev. B 50, 13 515...